Zebrafish Models of Major Depressive Disorders

被引:56
作者
Fonseka, Trehani M. [1 ,2 ]
Wen, Xiao-Yan [3 ,4 ,5 ]
Foster, Jane A. [1 ,6 ]
Kennedy, Sidney H. [1 ,2 ,3 ,5 ]
机构
[1] Univ Toronto, Dept Psychiat, Univ Hlth Network, Toronto, ON, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Psychiat, Toronto, ON, Canada
[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, Dept Med, Physiol, Toronto, ON, Canada
[5] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
基金
加拿大健康研究院; 加拿大创新基金会;
关键词
Danio rerio; stress; depression; antidepressants; high-throughput screen; behavior; GLUCOCORTICOID-RECEPTOR FUNCTION; PITUITARY-ADRENAL AXIS; ANXIETY-LIKE BEHAVIOR; MESSENGER-RNA EXPRESSION; BRAIN MONOAMINE-OXIDASE; ACUTE RESTRAINT STRESS; DANIO-RERIO; LARVAL ZEBRAFISH; BIPOLAR DISORDER; ADULT ZEBRAFISH;
D O I
10.1002/jnr.23639
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The zebrafish (Danio rerio) has emerged as a model species for translational research in various neuroscience areas, including depressive disorders. Because of their physiological (neuroanatomical, neuroendocrine, neurochemical) and genetic homology to mammals, robust phenotypes, and value in high-throughput genetic and chemical genetic screens, zebrafish are ideal for developing valid experimental models of major depression and discovering novel therapeutics. Behavioral testing approaches, such as approach-avoidance, cognitive, and social paradigms, are available in zebrafish and have utility in identifying depression-like indices in zebrafish in response to physiological, genetic, environmental, and/or psychopharmacological alterations. In addition, the high sensitivity of zebrafish to commonly prescribed psychotropic drugs supports the use of this model as an invaluable tool for pharmacological research and drug screening. This Review outlines the benefits of using the zebrafish model for depression studies and summarizes the current research in this field. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:3 / 14
页数:12
相关论文
共 137 条
[1]   Exploratory behaviour in the open field test adapted for larval zebrafish: Impact of environmental complexity [J].
Ahmad, Farooq ;
Richardson, Michael K. .
BEHAVIOURAL PROCESSES, 2013, 92 :88-98
[2]   HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions [J].
Aihara, Masako ;
Ida, Itsuro ;
Yuuki, Naoya ;
Oshima, Akihiko ;
Kurnano, Hiroshi ;
Takahashi, Keisuke ;
Fukuda, Masato ;
Oriuchi, Noboru ;
Endo, Keigo ;
Matsuda, Hiroshi ;
Mikuni, Masahiko .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2007, 155 (03) :245-256
[3]   Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC) [J].
Airhart, Mark J. ;
Lee, Deborah H. ;
Wilson, Tracy D. ;
Miller, Barney E. ;
Miller, Merry N. ;
Skalko, Richard G. .
NEUROTOXICOLOGY AND TERATOLOGY, 2007, 29 (06) :652-664
[4]   Adverse effects of serotonin depletion in developing zebrafish [J].
Airhart, Mark J. ;
Lee, Deborah H. ;
Wilson, Tracy D. ;
Miller, Barney E. ;
Miller, Merry N. ;
Skalko, Richard G. ;
Monaco, Paul J. .
NEUROTOXICOLOGY AND TERATOLOGY, 2012, 34 (01) :152-160
[5]   Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): Comparisons with human MAO A and MAO B [J].
Aldeco, Milagros ;
Arslan, Betuel Kacar ;
Edmondson, Dale E. .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2011, 159 (02) :78-83
[6]   The zebrafish stress axis: Molecular fallout from the teleost-specific genome duplication event [J].
Alsop, Derek ;
Vijayan, Mathilakath .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2009, 161 (01) :62-66
[7]   Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula [J].
Amo, Ryunosuke ;
Aizawa, Hidenori ;
Takahoko, Mikako ;
Kobayashi, Megumi ;
Takahashi, Rieko ;
Aoki, Tazu ;
Okamoto, Hitoshi .
JOURNAL OF NEUROSCIENCE, 2010, 30 (04) :1566-1574
[8]   Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio) [J].
Anichtchik, Oleg ;
Sallinen, Ville ;
Peitsaro, Nina ;
Panula, Pertti .
JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 498 (05) :593-610
[9]   Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects [J].
Barba-Escobedo, P. A. ;
Gould, G. G. .
GENES BRAIN AND BEHAVIOR, 2012, 11 (03) :366-373
[10]  
Barden N, 2004, J PSYCHIATR NEUROSCI, V29, P185