Zebrafish Models of Major Depressive Disorders

被引：56
作者：
Fonseka, Trehani M. [1 ,2 ]
Wen, Xiao-Yan [3 ,4 ,5 ]
Foster, Jane A. [1 ,6 ]
Kennedy, Sidney H. [1 ,2 ,3 ,5 ]
机构：
[1] Univ Toronto, Dept Psychiat, Univ Hlth Network, Toronto, ON, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Psychiat, Toronto, ON, Canada
[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, Dept Med, Physiol, Toronto, ON, Canada
[5] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2016年 / 94卷 / 01期
基金：
加拿大健康研究院; 加拿大创新基金会;
关键词：
Danio rerio; stress; depression; antidepressants; high-throughput screen; behavior; GLUCOCORTICOID-RECEPTOR FUNCTION; PITUITARY-ADRENAL AXIS; ANXIETY-LIKE BEHAVIOR; MESSENGER-RNA EXPRESSION; BRAIN MONOAMINE-OXIDASE; ACUTE RESTRAINT STRESS; DANIO-RERIO; LARVAL ZEBRAFISH; BIPOLAR DISORDER; ADULT ZEBRAFISH;
D O I：
10.1002/jnr.23639
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The zebrafish (Danio rerio) has emerged as a model species for translational research in various neuroscience areas, including depressive disorders. Because of their physiological (neuroanatomical, neuroendocrine, neurochemical) and genetic homology to mammals, robust phenotypes, and value in high-throughput genetic and chemical genetic screens, zebrafish are ideal for developing valid experimental models of major depression and discovering novel therapeutics. Behavioral testing approaches, such as approach-avoidance, cognitive, and social paradigms, are available in zebrafish and have utility in identifying depression-like indices in zebrafish in response to physiological, genetic, environmental, and/or psychopharmacological alterations. In addition, the high sensitivity of zebrafish to commonly prescribed psychotropic drugs supports the use of this model as an invaluable tool for pharmacological research and drug screening. This Review outlines the benefits of using the zebrafish model for depression studies and summarizes the current research in this field. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码：3 / 14
页数：12
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