Synthesis, Crystal Structure, and Cytotoxicity of a Copper(II) Complex With Matrine

被引：0

作者：

Mao, Li ^{[1
]}

Gu, Yun-Qiong ^{[1
]}

Liu, Yan-Cheng ^{[1
]}

Chen, Zhen-Feng ^{[1
]}

Liang, Hong ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Pharm & Chem, Guangxi Key Lab Chem & Mol Engn Med Resource, Guilin 541004, Peoples R China

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2014年 / 44卷 / 01期

基金：

中国国家自然科学基金;

关键词：

copper(II); crystal structure; cytotoxicity; matrine; DNA CLEAVAGE ACTIVITY; X-RAY-STRUCTURE; MIXED CHELATE; IN-VITRO; 3-CLIP-PHEN; DERIVATIVES; REACTIVITY; APOPTOSIS; BEHAVIOR; LINKER;

D O I：

10.1080/15533174.2013.768640

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new copper(II) complex ligated by the naturally occurring alkaloid matrine (MT), [Cu(MT+H)(2)(H2O)(3)](ClO4)(4) (1) was synthesized upon reacting matrine with Cu(ClO4)(2)6H(2)O. Characterized of complex 1 with elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction revealed the molecular structure to be a pentacoordinate copper(II) complex with two monodentate matrinium ions (MT+H) coordinated via carbonyl oxygen atoms and three aqua ligands. The positive charge of the cation [Cu(MT+H)(2)(H2O)(3)](4+) is balanced by four ClO- (4) anions. Complex 1 is cytotoxic toward MCF-7, SGC-7901, and SK-OV-3 tumor cell lines. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.

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页码：43 / 47

页数：5

相关论文

共 39 条

[1] Induction of oxidative damage by copper-based antineoplastic drugs (Casiopeinas®) [J].

Alemon-Medina, Radames ;

Brena-Valle, Matilde ;

Munoz-Sanchez, Jose Luis ;

Gracia-Mora, Maria Isabel ;

Ruiz-Azuara, Lena .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 60 (02) :219-228

[2] Synthesis and mass spectroscopy kinetics of a novel ternary copper(II) complex with cytotoxic activity against cancer cells [J].

Barcelo-Oliver, M. ;

Garcia-Raso, A. ;

Terron, A. ;

Molins, E. ;

Prieto, M. J. ;

Moreno, V. ;

Martinez, J. ;

Llado, V. ;

Lopez, I. ;

Gutierrez, A. ;

Escriba, P. V. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (04) :649-659

[3] Acridine conjugates of 3-Clip-Phen:: Influence of the linker on the synthesis and the DNA cleavage activity of their copper complexes [J].

Boldron, C ;

Ross, SA ;

Pitié, M ;

Meunier, B .

BIOCONJUGATE CHEMISTRY, 2002, 13 (05) :1013-1020

[4] Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo [J].

Carvallo-Chaigneau, Francisco ;

Trejo-Solis, Cristina ;

Gomez-Ruiz, Celedonio ;

Rodriguez-Aguilera, Ernesto ;

Macias-Rosales, Lucia ;

Cortes-Barberena, Edith ;

Cedillo-Pelaez, Carlos ;

Gracia-Mora, Isabel ;

Ruiz-Azuara, Lena ;

Madrid-Marina, Vicente ;

Constantino-Casas, Fernando .

BIOMETALS, 2008, 21 (01) :17-28

[5] Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) matrine with Ga(III), Au(III), Sn(IV) ions, and DNA binding studies [J].

Chen, Zhen-Feng ;

Mao, Li ;

Liu, Li-Min ;

Liu, Yan-Cheng ;

Peng, Yan ;

Hong, Xue ;

Wang, Hong-Hong ;

Liu, Hua-Gang ;

Liang, Hong .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (02) :171-180

[6] Progresses in TCM Metal-Based Antitumour Agents [J].

Chen, Zhen-Feng ;

Liang, Hong .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2010, 10 (05) :412-423

[7] Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry [J].

Chen, Zhen-Feng ;

Tan, Ming-Xiong ;

Liu, Li-Min ;

Liu, Yan-Cheng ;

Wang, Heng-Shan ;

Yang, Bin ;

Peng, Yan ;

Liu, Hua-Gang ;

Liang, Hong ;

Orvig, Chris .

DALTON TRANSACTIONS, 2009, (48) :10824-10833

[8] Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies [J].

Chen, Zhen-Feng ;

Liu, Yan-Cheng ;

Liu, Li-Min ;

Wang, Heng-Shan ;

Qin, San-Hai ;

Wang, Bo-Long ;

Bian, He-Dong ;

Yang, Bin ;

Fun, Hoong-Kun ;

Liu, Hua-Gang ;

Liang, Hong ;

Orvig, Chris .

DALTON TRANSACTIONS, 2009, (02) :262-272

[9] Antimutagenicity, cytotoxicity and composition of chlorophyllin copper complex [J].

Chernomorsky, S ;

Rancourt, R ;

Virdi, K ;

Segelman, A ;

Poretz, RD .

CANCER LETTERS, 1997, 120 (02) :141-147

[10] Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex [J].

Cini, Renzo ;

Tamasi, Gabriella ;

Defazio, Sandra ;

Hursthouse, Michael B. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (08) :1140-1152

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