Influence of 1,3-Difluorobenzene Substituents for Palladium-Catalyzed Direct Arylations

被引：10

作者：

Yan, Tao ^{[1
]}

Bheeter, Charles Beromeo ^{[1
]}

Doucet, Henri ^{[1
]}

机构：

[1] Univ Rennes 1, Inst Sci Chim Rennes, UMR 6226, CNRS, F-35042 Rennes, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 31期

关键词：

Palladium; Biaryls; Cross-coupling; C-C coupling; C-H activation; Regioselectivity; INTERMOLECULAR DIRECT ARYLATION; CROSS-COUPLING REACTIONS; HETEROAROMATIC-COMPOUNDS; STRAIGHTFORWARD ACCESS; ARYL BROMIDES; POLYFLUOROARENES; DERIVATIVES; MECHANISM; HALIDES; MILD;

D O I：

10.1002/ejoc.201301131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The influence of electron-withdrawing and electron-donating substituents (nitro, nitrile, chloro, bromo, methoxy or amino) on 1,3-difluorobenzenes in their palladium-catalysed direct C2 arylation has been explored. With most substituents, the reaction proceeds nicely using air-stable palladium catalysts (0.5-2 mol-%) and KOAc/DMA. In general, very regioselective C2-arylation was observed. Moreover, a variety of substituents on the aryl bromide coupling partner (ester, acetyl, formyl, nitro, nitrile, trifluoromethyl, chloro, fluoro or methyl) was tolerated.

引用

页码：7152 / 7163

页数：12

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