MicroRNAs as Molecular Switches in Macrophage Activation

被引：152

作者：

Curtale, Graziella ^{[1
,2
]}

Rubino, Marcello ^{[2
,3
]}

Locati, Massimo ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy

[2] Humanitas Clin & Res Ctr IRCCS, Rozzano, Italy

[3] Univ Colorado, Dept Med, Div Cardiol, Anschultz Med Campus, Denver, CO USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

macrophages; microRNA; endotoxin; Toll-like receptor; TAM; NF-KAPPA-B; TUMOR-ASSOCIATED MACROPHAGES; MYCOBACTERIUM-TUBERCULOSIS INFECTION; INNATE IMMUNE MEMORY; INFLAMMATORY RESPONSES; TRANSCRIPTIONAL PROGRAM; PATHOGEN RECOGNITION; NEGATIVE REGULATION; TARGET RECOGNITION; REGULATORY NETWORK;

D O I：

10.3389/fimmu.2019.00799

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of macrophage-mediated inflammatory response relies on the coordinated expression of key factors, which expression is finely regulated at both transcriptional and post-transcriptional level. Several studies have provided compelling evidence that microRNAs play pivotal roles in modulating macrophage activation, polarization, tissue in filtration, and resolution of inflammation. In this review, we highlight the essential molecular mechanisms underlying the different phases of inflammation that are targeted by microRNAs to inhibit or accelerate restoration to tissue integrity and homeostasis. We further review the impact of microRNA-dependent regulation of tumor-associated macrophages and the relative implication for tumor biology.

引用

页数：13

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