Peculiarities of Determining Bacterial Endotoxins in Oil Solutions of Drugs

被引：0
作者：
Shapovalova, O. V. [1 ]
Neugodova, N. P. [1 ]
Sapozhnikova, G. A. [1 ]
机构：
[1] Minist Hlth Russian Federat, Sci Ctr Expert Evaluat Med Prod, 8-2 Petrovskii Blvd, Moscow 127051, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2020年 / 54卷 / 05期
关键词：
bacterial endotoxins; extraction; oil solutions; dispersing solvent;
D O I：
10.1007/s11094-020-02234-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Issues related to reliable quality assessment of oil solutions of medicines with respect to the Bacterial Endotoxins indicator are considered. The maximum isolation of bacterial endotoxins from fat-soluble drugs for subsequent determination is assisted by vigorous stirring of samples in water previously heated to 60 degrees C followed by separation of the two phases using centrifugation at 2300 rpm for 10 min.
引用
收藏
页码：539 / 543
页数：5
相关论文
共 12 条
  • [1] [Anonymous], 2013, TESTING OIL SOLUTION
  • [2] [Anonymous], 2014, NECESSITY LAL ENDOTO
  • [3] Arambasic M. B., 2012, C PAPER
  • [4] Arambasic M. B., 2010, C PAPER
  • [5] A New Method for the Analysis of Bacterial Endotoxins in Ultrapure Paraffin Oil
    Chen, Dandan
    [J]. JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY, 2014, 2014
  • [6] Chueshov V. I., 2010, TECHNOLOGY INDUSTRIA
  • [7] Ievleva A. A., 2012, HDB BASIC DRUGS
  • [8] Lavrenchuk R. A., 2012, VEDOM NAUCHN TSENTRA, P40
  • [9] Merkulova Yu. V., 2008, FARMAKOM, P67
  • [10] Pennamareddy R., 2010, THESIS, P123
12