Human Polynucleotide Phosphorylase (hPNPaseold-35): Should I Eat You or Not-That Is the Question?

被引：10

作者：

Sokhi, Upneet K. ^{[1
]}

Das, Swadesh K. ^{[1
,2
]}

Dasgupta, Santanu ^{[1
,2
,3
]}

Emdad, Luni ^{[1
,2
,3
]}

Shiang, Rita ^{[1
]}

DeSalle, Robert ^{[2
,4
,5
]}

Sarkar, Devanand ^{[1
,2
,3
]}

Fisher, Paul B. ^{[1
,2
,3
]}

机构：

[1] Virginia Commonwealth Univ, Dept Human & Mol Genet, Sch Med, Richmond, VA 23284 USA

[2] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA USA

[3] Virginia Commonwealth Univ, VCU Massey Canc Ctr, Sch Med, Richmond, VA USA

[4] Amer Museum Nat Hist, Sackler Inst Comparat Genom, New York, NY 10024 USA

[5] NYU, New York, NY USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 119 | 2013年 / 119卷

关键词：

MESSENGER-RNA DEGRADATION; DOUBLE-STRANDED-RNA; FACTOR-KAPPA-B; TERMINAL DIFFERENTIATION; TRANSCRIPTION FACTOR; CRYSTAL-STRUCTURE; GENE-EXPRESSION; QUALITY-CONTROL; GROWTH ARREST; PNPASE;

D O I：

10.1016/B978-0-12-407190-2.00005-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA degradation plays a fundamental role in maintaining cellular homeostasis whether it occurs as a surveillance mechanism eliminating aberrant mRNAs or during RNA processing to generate mature transcripts. 3'-5' exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPase(old-35)) was cloned a decade ago in the context of terminal differentiation and senescence through a novel "overlapping pathway screening" approach. Since then, significant insights have been garnered about this exoribonuclease and its repertoire of expanding functions. The objective of this review is to provide an up-to-date perspective of the recent discoveries made relating to hPNPase(old-35) and the impact they continue to have on our comprehension of its expanding and diverse array of functions.

引用

页码：161 / 190

页数：30

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