Transient receptor potential channel superfamily: Role in lower urinary tract function

被引：1

作者：

Ogawa, Teruyuki ^{[1
]}

Imamura, Tetsuya ^{[1
]}

Nakazawa, Masaki ^{[1
]}

Hiragata, Shiro ^{[1
]}

Nagai, Takashi ^{[1
]}

Minagawa, Tomonori ^{[1
]}

Yokoyama, Hitoshi ^{[1
]}

Ishikawa, Masakuni ^{[1
]}

Domen, Takahisa ^{[1
]}

Ishizuka, Osamu ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 3908621, Japan

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2015年 / 22卷 / 11期

关键词：

bladder; lower urinary tract; transient receptor potential; CATION CHANNEL; VANILLOID RECEPTOR; CAPSAICIN RECEPTOR; HUMAN BLADDER; INTRAVESICAL CAPSAICIN; DETRUSOR OVERACTIVITY; SENSITIVE NERVES; TRPM8; CHANNELS; ION-CHANNEL; CA2+ INFLUX;

D O I：

10.1111/iju.12861

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lower urinary tract symptoms associated with neurogenic bladder and overactive bladder syndrome are mediated in part by members of the transient receptor potential channel superfamily. The best studied member of this superfamily is the vanilloid receptor. Other transient receptor potential channels, such as the melastatin receptor and the ankyrin receptor, are also active in the pathogenesis of lower urinary tract dysfunction. However, the detailed mechanisms by which the transient receptor potential channels contribute to lower urinary tract symptoms are still not clear, and the therapeutic benefits of modulating transient receptor potential channel activity have not been proved in the clinical setting. In the present review, to better understand the pathophysiology and therapeutic potential for lower urinary tract symptoms, we summarize the presence and role of different members of the transient receptor potential channel superfamily in the lower urinary tract.

引用

页码：994 / 999

页数：6

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