Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum

被引：54

作者：

Cerovic, Milica ^{[1
]}

d'Isa, Raffaele ^{[2
]}

Tonini, Raffaella ^{[3
]}

Brambilla, Riccardo ^{[2
]}

机构：

[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales

[2] San Raffaele Sci Inst & Univ, Inst Expt Neurol, Div Neurosci, I-20132 Milan, Italy

[3] Ist Italiano Tecnol, Neurosci & Brain Technol Dept, I-16163 Genoa, Italy

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2013年 / 105卷

关键词：

Striatum; Nucleus accumbens; Basal ganglia; Long-term potentiation; Long-term depression; Instrumental learning; L-DOPA induced dyskinesia; Drug addiction; Ras-ERK signaling; Endocannabinoids; LONG-TERM DEPRESSION; SIGNAL-REGULATED KINASE; MEDIUM SPINY NEURONS; NUCLEUS-ACCUMBENS CORE; BIDIRECTIONAL SYNAPTIC PLASTICITY; ACTIVITY-DEPENDENT PLASTICITY; ELEMENT-BINDING PROTEIN; BASAL GANGLIA; INDIRECT PATHWAYS; MEMORY-SYSTEMS;

D O I：

10.1016/j.nlm.2013.06.013

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The striatum is the input structure of the basal ganglia system. By integrating glutamatergic signals from cortical and subcortical regions and dopaminergic signals from mesolimbic nuclei the striatum functions as an important neural substrate for procedural and motor learning as well as for reward-guided behaviors. In addition, striatal activity is significantly altered in pathological conditions in which either a loss of dopamine innervation (Parkinson's disease) or aberrant dopamine-mediated signaling (drug addiction and L-DOPA induced dyskinesia) occurs. Here we discuss cellular mechanisms of striatal synaptic plasticity and aspects of cell signaling underlying striatum-dependent behavior, with a major focus on the neuromodulatory action of the endocannabinoid system and on the role of the Ras-ERK cascade. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：63 / 80

页数：18

共 248 条

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