Ubiquitin ligase Cbl-b and inhibitory Cblin peptides

被引：10

作者：

Nikawa, Takeshi ^{[1
]}

Ishidoh, Kazumi ^{[2
]}

机构：

[1] Tokushima Univ, Inst Med Nutr, Dept Nutr Physiol, Grad Sch, Kuramoto Cho, Tokushima 7708503, Japan

[2] Tokushima Bunri Univ, Inst Hlth Sci, Yamashiro Cho, Tokushima, Tokushima 7708514, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2020年 / 1868卷 / 11期

关键词：

MAFbx-1/atrogin-1; MuRF-1; Cbl-b; Cblin; Muscle atrophy; MYOSIN HEAVY-CHAIN; SKELETAL-MUSCLE; PROTEIN; ATROPHY; ACTIVATION; EXPRESSION; DOMAIN; PHOSPHORYLATION; IDENTIFICATION; DEGRADATION;

D O I：

10.1016/j.bbapap.2020.140495

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the Cbl-b muscle atrophy-associated ubiquitin ligase and its inhibitors. Herein, the role of E3 ubiquitin ligase-associated muscle atrophy genes (atrogenes), including MAFbx-1/agrogin-1 and MuRF-1, as well as another ubiquitin ligase, Cbl-b and its inhibitors, is discussed. Cbl-b plays an important role in unloading muscle atrophy caused by spaceflight and in bedridden patients: Cbl-b ubiquitinated and induced the degradation of IRS-1, a key intermediate in the IGF-1 signaling. Furthermore, a pentapetpide (DGpYMP), inhibited Cbl-b-mediated IRS-1 ubiquitination. This peptide-based Cbl-b inhibitor Cblin and its homologous peptides in foods presumably affect muscle atrophy under such conditions.

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页数：6

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共 32 条

[1] Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle-Atrophy-Associated Ubiquitin Ligase Cbl-b [J].

Abe, Tomoki ;

Kohno, Shohei ;

Yama, Tomonari ;

Ochi, Arisa ;

Suto, Takuro ;

Hirasaka, Katsuya ;

Ohno, Ayako ;

Teshima-Kondo, Shigetada ;

Okumura, Yuushi ;

Oarada, Motoko ;

Choi, Inho ;

Mukai, Rie ;

Terao, Junji ;

Nikawa, Takeshi .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013, 2013

[2] Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats [J].

Anthony, Tracy G. ;

McDaniel, Brent J. ;

Knoll, Peter ;

Bunpo, Piyawan ;

Paul, Greg L. ;

McNurlan, Margaret A. .

JOURNAL OF NUTRITION, 2007, 137 (02) :357-362

[3] Identification of ubiquitin ligases required for skeletal muscle atrophy [J].

Bodine, SC ;

Latres, E ;

Baumhueter, S ;

Lai, VKM ;

Nunez, L ;

Clarke, BA ;

Poueymirou, WT ;

Panaro, FJ ;

Na, EQ ;

Dharmarajan, K ;

Pan, ZQ ;

Valenzuela, DM ;

DeChiara, TM ;

Stitt, TN ;

Yancopoulos, GD ;

Glass, DJ .

SCIENCE, 2001, 294 (5547) :1704-1708

[4] Phosphorylation of IRS proteins, insulin action, and insulin resistance [J].

Boura-Halfon, Sigalit ;

Zick, Yehiel .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (04) :E581-E591

[5] Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain [J].

Centner, T ;

Yano, J ;

Kimura, E ;

McElhinny, AS ;

Pelin, K ;

Witt, CC ;

Bang, ML ;

Trombitas, K ;

Granzier, H ;

Gregorio, CC ;

Sorimachi, H ;

Labeit, S .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 306 (04) :717-726

[6] Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities [J].

Chakrabarti, Subhadeep ;

Guha, Snigdha ;

Majumder, Kaustav .

NUTRIENTS, 2018, 10 (11)

[7] Regulation of Cullin RING E3 Ubiquitin Ligases by CAND1 In Vivo [J].

Chua, Yee Shin ;

Boh, Boon Kim ;

Ponyeam, Wanpen ;

Hagen, Thilo .

PLOS ONE, 2011, 6 (01)

[8] The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle [J].

Clarke, Brian A. ;

Drujan, Doreen ;

Willis, Monte S. ;

Murphy, Leon O. ;

Corpina, Richard A. ;

Burova, Elena ;

Rakhilin, Sergey V. ;

Stitt, Trevor N. ;

Patterson, Cam ;

Latres, Esther ;

Glass, David J. .

CELL METABOLISM, 2007, 6 (05) :376-385

[9] MAFbx/Atrogin-1 Controls the Activity of the Initiation Factor eIF3-f in Skeletal Muscle Atrophy by Targeting Multiple C-terminal Lysines [J].

Csibi, Alfredo ;

Leibovitch, Marie Pierre ;

Cornille, Karen ;

Tintignac, Lionel A. ;

Leibovitch, Serge A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (07) :4413-4421

[10] Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells [J].

Esposito, DL ;

Li, YH ;

Cama, A ;

Quon, MJ .

ENDOCRINOLOGY, 2001, 142 (07) :2833-2840

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