γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

被引：240

作者：

Kohlgruber, Ayano C. ^{[1
,2
]}

Gal-Oz, Shani T. ^{[3
]}

LaMarche, Nelson M. ^{[1
,2
]}

Shimazaki, Moto ^{[1
]}

Duquette, Danielle ^{[4
]}

Nguyen, Hung N. ^{[1
]}

Mina, Amir I. ^{[4
]}

Paras, Tyler ^{[1
]}

Tavakkoli, Ali ^{[5
]}

von Andrian, Ulrich ^{[2
,6
]}

Banks, Alexander S. ^{[4
]}

Shay, Tal ^{[3
]}

Brenner, Michael B. ^{[1
]}

Lynch, Lydia ^{[1
,4
,7
]}

机构：

[1] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Div Med Sci, Boston, MA USA

[3] Ben Gurion Univ Negev, Dept Life Sci, Beer Sheva, Israel

[4] Brigham & Womens Hosp, Dept Med, Div Endocrinol, 75 Francis St, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Dept Gen & Gastrointestinal Surg, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Dept Microbiol & Immunol, Boston, MA USA

[7] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 05期

基金：

欧洲研究理事会;

关键词：

INNATE LYMPHOID TYPE-2; PLZF CONTROLS; TISSUE; IL-33; FAT; ACCUMULATION; GENE; ACTIVATION; EXPRESSION; PHENOTYPE;

D O I：

10.1038/s41590-018-0094-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

gamma delta T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles outside of host defense in nonbarrier tissues. Here, we characterize a highly enriched tissue-resident population of gamma delta T cells in adipose tissue that regulate age-dependent regulatory T cell (T-reg) expansion and control core body temperature in response to environmental fluctuations. Mechanistically, innate PLZF(+) gamma delta T cells produced tumor necrosis factor and interleukin (IL) 17 A and determined PDGFR alpha(+) and Pdpn(+) stromal-cell production of IL-33 in adipose tissue. Mice lacking gamma delta T cells or IL-17A exhibited decreases in both ST2(+) T-reg cells and IL-33 abundance in visceral adipose tissue. Remarkably, these mice also lacked the ability to regulate core body temperature at thermoneutrality and after cold challenge. Together, these findings uncover important physiological roles for resident gamma delta T cells in adipose tissue immune homeostasis and body-temperature control.

引用

页码：464 / +

页数：13

共 47 条

[1] Development of PLZF-expressing innate T cells [J].