Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

被引:41
作者
Chang, Ernest W. [1 ,2 ]
Cheng, Jeffrey T. [3 ,4 ]
Roeoesli, Christof [3 ,4 ,5 ]
Kobler, James B. [6 ,7 ]
Rosowski, John J. [3 ,4 ,8 ]
Yun, Seok Hyun [1 ,8 ,9 ]
机构
[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA
[4] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA
[5] Univ Zurich Hosp, Dept Otorhinolaryngol Head & Neck Surg, Zurich, Switzerland
[6] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA
[7] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA
[8] Harvard MIT Hlth Sci & Technol, Cambridge, MA USA
[9] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA
关键词
OPTICAL COHERENCE TOMOGRAPHY; IN-VIVO; HEARING-LOSS; LASER; CHINCHILLA; VELOCITY; SURFACE; EARDRUM; INTERFEROMETRY; FEASIBILITY;
D O I
10.1016/j.heares.2013.06.006
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Efficient transfer of sound by the middle ear ossicles is essential for hearing. Various pathologies can impede the transmission of sound and thereby cause conductive hearing loss. Differential diagnosis of ossicular disorders can be challenging since the ossicles are normally hidden behind the tympanic membrane (TM). Here we describe the use of a technique termed optical coherence tomography (OCT) vibrography to view the sound-induced motion of the TM and ossicles simultaneously. With this method, we were able to capture three-dimensional motion of the intact TM and ossicles of the chinchilla ear with nanometer-scale sensitivity at sound frequencies from 0.5 to 5 kHz. The vibration patterns of the TM were complex and highly frequency dependent with mean amplitudes of 70-120 nm at 100 dB sound pressure level. The TM motion was only marginally sensitive to stapes fixation and incus-stapes joint interruption; however, when additional information derived from the simultaneous measurement of ossicular motion was added, it was possible to clearly distinguish these different simulated pathologies. The technique may be applicable to clinical diagnosis in Otology and to basic research in audition and acoustics. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:49 / 56
页数:8
相关论文
共 41 条
  • [1] Quantification of a three-dimensional velocity vector using spectral-domain Doppler optical coherence tomography
    Ahn, Yeh-Chan
    Jung, Woonggyu
    Chen, Zhongping
    [J]. OPTICS LETTERS, 2007, 32 (11) : 1587 - 1589
  • [2] Subnanometer optical coherence tomographic vibrography
    Chang, Ernest W.
    Kobler, James B.
    Yun, Seok H.
    [J]. OPTICS LETTERS, 2012, 37 (17) : 3678 - 3680
  • [3] A differentially amplified motion in the ear for near-threshold sound detection
    Chen, Fangyi
    Zha, Dingjun
    Fridberger, Anders
    Zheng, Jiefu
    Choudhury, Niloy
    Jacques, Steven L.
    Wang, Ruikang K.
    Shi, Xiaorui
    Nuttall, Alfred L.
    [J]. NATURE NEUROSCIENCE, 2011, 14 (06) : 770 - U366
  • [4] Wave motion on the surface of the human tympanic membrane: Holographic measurement and modeling analysis
    Cheng, Jeffrey Tao
    Hamade, Mohamad
    Merchant, Saumil N.
    Rosowski, John J.
    Harrington, Ellery
    Furlong, Cosme
    [J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2013, 133 (02) : 918 - 937
  • [5] Motion of the surface of the human tympanic membrane measured with stroboscopic holography
    Cheng, Jeffrey Tao
    Aarnisalo, Antti A.
    Harrington, Ellery
    Hernandez-Montes, Maria del Socorro
    Furlong, Cosme
    Merchant, Saumil N.
    Rosowski, John J.
    [J]. HEARING RESEARCH, 2010, 263 (1-2) : 66 - 77
  • [6] Measurements of stapes velocity in live human ears
    Chien, Wade
    Rosowski, John J.
    Ravicz, Michael E.
    Rauch, Steven D.
    Smullen, Jennifer
    Merchant, Saumil N.
    [J]. HEARING RESEARCH, 2009, 249 (1-2) : 54 - 61
  • [7] TYMPANOMETRY IN THE DETECTION OF HEARING IMPAIRMENTS ASSOCIATED WITH OTITIS-MEDIA WITH EFFUSION
    DEMPSTER, JH
    MACKENZIE, K
    [J]. CLINICAL OTOLARYNGOLOGY, 1991, 16 (02) : 157 - 159
  • [8] Malleostapedotomy in revision surgery for otosclerosis
    Fisch, U
    Acar, GÖ
    Huber, AM
    [J]. OTOLOGY & NEUROTOLOGY, 2001, 22 (06) : 776 - 785
  • [9] ON THE UNDAMPED NATURAL FREQUENCIES AND MODE SHAPES OF A FINITE-ELEMENT MODEL OF THE CAT EARDRUM
    FUNNELL, WRJ
    [J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1983, 73 (05) : 1657 - 1661
  • [10] Modeling the eardrum as a string with distributed force
    Goll, Erich
    Dalhoff, Ernst
    [J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2011, 130 (03) : 1452 - 1462