NLRP6 in infection and inflammation

被引：34
作者：
Anand, Paras K. [1 ]
Kanneganti, Thirumala-Devi [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源：
MICROBES AND INFECTION | 2013年 / 15卷 / 10-11期
基金：
美国国家卫生研究院;
关键词：
NLRP6; NLR; Innate immunity; Infection; Microbiota; Intestinal homeostasis; NF-KAPPA-B; PPAR-GAMMA; LISTERIA-MONOCYTOGENES; INNATE IMMUNITY; COLORECTAL CARCINOGENESIS; INTESTINAL INFLAMMATION; COLON INFLAMMATION; ADAPTIVE IMMUNITY; CHEMOKINE RANTES; CHRONIC COLITIS;
D O I：
10.1016/j.micinf.2013.06.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
NLRs play fundamental roles in host-defense and inflammatory disorders. NLRP6 is a newly characterized member of this family that inhibits NF-kappa B and MAP-kinase dependent immune signaling to hamper anti-microbial defense. Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6. (c) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：661 / 668
页数：8
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