Study on the expression of RXRα in patients with psoriasis vulgaris

被引：0

作者：

Feng, SY ^{[1
]}

Lin, L ^{[1
]}

Wu, QX ^{[1
]}

Zhou, WQ ^{[1
]}

Shao, CG ^{[1
]}

机构：

[1] Peking Union Med Coll, Chinese Acad Med Sci, Inst Dermatol, Nanjing 210042, Peoples R China

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2006年 / 16卷 / 01期

关键词：

psoriasis; RXR alpha;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Retinoic acid regulates keratinocyte proliferation and differentiation processes that are disturbed in psoriatic skin - via binding to nuclear receptors, including retinoic acid receptor (RAR-alpha,beta,gamma) and the common heterodimer partners (RXR-alpha,beta,gamma). By RT-PCR and immunohistochemistry methods, the expression of RXR alpha was studied in psoriatic skin and controls. The expression of RXR alpha was down-regulated in patients with psoriasis; moreover, its level was related to the stage of the disease; in the progressive stage of the disease, the level of the RXR alpha was lower than in the stable stage. The results suggest that retinoid signaling is abnormal in lesional psoriatic skin, RXR alpha expression is mainly confined to differentiated keratinocytes.

引用

页码：33 / 38

页数：6

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