Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

被引：54

作者：

Chen, Tao ^{[1
]}

Su, Lichao ^{[1
]}

Ge, Xiaoguang ^{[1
]}

Zhang, Wenmin ^{[1
]}

Li, Qingqing ^{[1
]}

Zhang, Xuan ^{[1
]}

Ye, Jiamin ^{[1
]}

Lin, Lisen ^{[1
]}

Song, Jibin ^{[1
]}

Yang, Huanghao ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China

来源：

NANO RESEARCH | 2020年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

radiotherapy; second near-infrared window (NIR-II); fluorescence imaging; photoacoustic imaging; plasmonic gold nanovesicle; NEAR-INFRARED WINDOW; CARBON NANOTUBES; NANOPARTICLES; NANOCRYSTALS; VESICLES; PLATFORM; SURGERY;

D O I：

10.1007/s12274-020-3000-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.

引用

页码：3268 / 3277

页数：10

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