Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

被引：54

作者：

Chen, Tao ^{[1
]}

Su, Lichao ^{[1
]}

Ge, Xiaoguang ^{[1
]}

Zhang, Wenmin ^{[1
]}

Li, Qingqing ^{[1
]}

Zhang, Xuan ^{[1
]}

Ye, Jiamin ^{[1
]}

Lin, Lisen ^{[1
]}

Song, Jibin ^{[1
]}

Yang, Huanghao ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China

来源：

NANO RESEARCH | 2020年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

radiotherapy; second near-infrared window (NIR-II); fluorescence imaging; photoacoustic imaging; plasmonic gold nanovesicle; NEAR-INFRARED WINDOW; CARBON NANOTUBES; NANOPARTICLES; NANOCRYSTALS; VESICLES; PLATFORM; SURGERY;

D O I：

10.1007/s12274-020-3000-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.

引用

页码：3268 / 3277

页数：10

共 37 条

[21] Janus Nanoprobe with Dual-Modal NIR-II Fluorescence/Photoacoustic Imaging for Precision Cancer Radiosensitizing Therapy [J].

Wang, Shiyu ;

Liu, Wenzheng ;

Cao, Yixi ;

Wang, Jimei ;

Zhu, Kang ;

Li, Zhanyuan ;

Cao, Jingjing ;

Mo, Chunxiang ;

Chen, Qing ;

Huang, Wei ;

Wu, Ying ;

Chen, Ling ;

Song, Jibin .

ACS APPLIED MATERIALS & INTERFACES, 2025, 17 (20) :29266-29275

[22] A-DA'D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy [J].

Yang, Ke ;

Long, Fei ;

Liu, Wei ;

Zhang, Zequn ;

Zhao, Shaojing ;

Wang, Benhua ;

Zou, Yingping ;

Lan, Minhuan ;

Yuan, Jun ;

Song, Xiangzhi ;

Lin, Changwei .

ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (16) :18043-18052

[23] GSH responsive AuNRs@TFF nanotheranostic for NIR-II photoacoustic imaging-guided CDT/PTT synergistic cancer therapy [J].

Leng, Nan ;

Zhou, Yuzhu ;

Wen, Changchun ;

Fang, Qi ;

Guo, Xiaohuan ;

Cai, Bingbing ;

Huang, Ke-Bin ;

Liang, Hong .

BIOMATERIALS ADVANCES, 2025, 166

[24] A self-assembled Ru nanozyme with H2O2-activated oxygenation for NIR-II photoacoustic imaging-guided photothermal/photodynamic therapy [J].

Liu, Guang ;

Li, Zhilang ;

Lv, Zirong ;

Zheng, Qiuping ;

Gao, Cunji ;

Tian, Jianniao ;

Shen, Xing-Can .

MATERIALS ADVANCES, 2024, 5 (11) :4902-4912

[25] Lutetium-Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR-II Fluorescence Imaging-Guided Surgery in Colorectal Cancer [J].

Dang, Yongying ;

Liu, Xianzhi ;

Zheng, Zifan ;

Wang, Ao ;

Huang, Ying ;

Luo, Zhong ;

Tian, Haina ;

Li, Siyaqi ;

Luo, Qiang ;

Wang, Peiyuan ;

He, Weiling .

ADVANCED SCIENCE, 2025,

[26] Hydrogen Sulfide Dual-Activated NIR-II Photoacoustic Probes for Accurate Imaging and Efficient Photothermal Therapy of Colon Cancer [J].

Wang, Shulong ;

Zhang, Liangliang ;

Zhao, Jingjin ;

Hou, Li ;

Wen, Changchun ;

Liang, Hong ;

Zhao, Shulin .

ACS APPLIED BIO MATERIALS, 2021, 4 (01) :974-983

[27] NIR-II Dye-Based Multifunctional Telechelic Glycopolymers for NIR-IIa Fluorescence Imaging-Guided Stimuli-Responsive Chemo-Photothermal Combination Therapy [J].

Chen, Shangyu ;

Sun, Bo ;

Miao, Han ;

Wang, Gaina ;

Sun, Pengfei ;

Li, Jiewei ;

Wang, Wenjun ;

Fan, Quli ;

Huang, Wei .

ACS MATERIALS LETTERS, 2020, 2 (02) :174-183

[28] Self-Assembled Ag2S-QD Vesicles for In Situ Responsive NIR-II Fluorescence Imaging-Guided Photothermal Cancer Therapy [J].

Liu, Tianji ;

Zhang, Xuan ;

Liu, Dezhi ;

Chen, Bin ;

Ge, Xiaoguang ;

Gao, Shi ;

Song, Jibin .

ADVANCED OPTICAL MATERIALS, 2021, 9 (12)

[29] Biotin-decorated hollow gold nanoshells for dual-modal imaging-guided NIR-II photothermal and radiosensitizing therapy toward breast cancer [J].

Chen, Yongjian ;

Meng, Wei ;

Chen, Ming ;

Zhang, Lianying ;

Chen, Mingwa ;

Chen, Xiaotong ;

Peng, Jian ;

Huang, Naihan ;

Zhang, Wenhua ;

Chen, Jinxiang .

JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (41) :10003-10018

[30] Highly bright aggregation-induced emission nanodots for precise photoacoustic/NIR-II fluorescence imaging-guided resection of neuroendocrine neoplasms and sentinel lymph nodes [J].

Xu, Ruitong ;

Jiao, Di ;

Long, Qin ;

Li, Xiaolin ;

Shan, Ke ;

Kong, Xianglong ;

Ou, Hanlin ;

Ding, Dan ;

Tang, Qiyun .

BIOMATERIALS, 2022, 289

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