Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

被引：54
作者：
Chen, Tao [1 ]
Su, Lichao [1 ]
Ge, Xiaoguang [1 ]
Zhang, Wenmin [1 ]
Li, Qingqing [1 ]
Zhang, Xuan [1 ]
Ye, Jiamin [1 ]
Lin, Lisen [1 ]
Song, Jibin [1 ]
Yang, Huanghao [1 ]
机构：
[1] Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China
来源：
NANO RESEARCH | 2020年 / 13卷 / 12期
基金：
中国国家自然科学基金;
关键词：
radiotherapy; second near-infrared window (NIR-II); fluorescence imaging; photoacoustic imaging; plasmonic gold nanovesicle; NEAR-INFRARED WINDOW; CARBON NANOTUBES; NANOPARTICLES; NANOCRYSTALS; VESICLES; PLATFORM; SURGERY;
D O I：
10.1007/s12274-020-3000-9
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.
引用
收藏
页码：3268 / 3277
页数：10
相关论文
共 59 条
[31]   Ultra-small nanocluster mediated synthesis of Nd3+-doped core-shell nanocrystals with emission in the second near-infrared window for multimodal imaging of tumor vasculature [J].
Ren, Feng ;
Ding, Lihua ;
Liu, Hanghang ;
Huang, Qian ;
Zhang, Hao ;
Zhang, Lijuan ;
Zeng, Jianfeng ;
Sun, Qiao ;
Li, Zhen ;
Gao, Mingyuan .
BIOMATERIALS, 2018, 175 :30-43
[32]   In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake [J].
Robinson, Joshua T. ;
Hong, Guosong ;
Liang, Yongye ;
Zhang, Bo ;
Yaghi, Omar K. ;
Dai, Hongjie .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (25) :10664-10669
[33]   Self-Assembled Responsive Bilayered Vesicles with Adjustable Oxidative Stress for Enhanced Cancer Imaging and Therapy [J].
Song, Jibin ;
Lin, Lisen ;
Yang, Zhen ;
Zhu, Rong ;
Zhou, Zijian ;
Li, Zhan-Wei ;
Wang, Feng ;
Chen, Jingyi ;
Yang, Huanghao ;
Chen, Xiaoyuan .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (20) :8158-8170
[34]   Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low-Dose X-Ray-Induced Deep-Penetrating Photodynamic Therapy [J].
Sun, Wenjing ;
Shi, Tianhang ;
Luo, Li ;
Chen, Xiaomei ;
Lv, Peng ;
Lv, Ying ;
Zhuang, Yixi ;
Zhu, Jinjie ;
Liu, Gang ;
Chen, Xiaoyuan ;
Chen, Hongmin .
ADVANCED MATERIALS, 2019, 31 (16)
[35]   Organic Semiconducting Photoacoustic Nanodroplets for Laser-Activatable Ultrasound Imaging and Combinational Cancer Therapy [J].
Tang, Wei ;
Yang, Zhen ;
Wang, Sheng ;
Wang, Zhantong ;
Song, Jibin ;
Yu, Guocan ;
Fan, Wenpei ;
Dai, Yunlu ;
Wang, Jingjing ;
Shan, Lingling ;
Niu, Gang ;
Fan, Quli ;
Chen, Xiaoyuan .
ACS NANO, 2018, 12 (03) :2610-2622
[36]   Au Nanorod Design as Light-Absorber in the First and Second Biological Near-Infrared Windows for in Vivo Photothermal Therapy [J].
Tsai, Ming-Fong ;
Chang, Shih-Hui Gilbert ;
Cheng, Fong-Yu ;
Shanmugam, Vijayakumar ;
Cheng, Yu-Sheng ;
Su, Chia-Hao ;
Yeh, Chen-Sheng .
ACS NANO, 2013, 7 (06) :5330-5342
[37]   Near-Infrared-Light-Activatable Nanomaterial-Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment [J].
Vankayala, Raviraj ;
Hwang, Kuo Chu .
ADVANCED MATERIALS, 2018, 30 (23)
[38]   Ag, Ag2S, and Ag2Se nanocrystals:: Synthesis, assembly, and construction of mesoporous structures [J].
Wang, Dingsheng ;
Xie, Ting ;
Peng, Qing ;
Li, Yadong .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (12) :4016-4022
[39]   Fabrication of Red Blood Cell-Based Multimodal Theranostic Probes for Second Near-Infrared Window Fluorescence Imaging-Guided Tumor Surgery and Photodynamic Therapy [J].
Wang, Peiyuan ;
Wang, Xuandonga ;
Luo, Qian ;
Lil, Yang ;
Lin, Xiaoxiao ;
Fan, Lingling ;
Zhang, Yun ;
Liu, Jingfeng ;
Liu, Xiaolong .
THERANOSTICS, 2019, 9 (02) :369-380
[40]   NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer [J].
Wang, Peiyuan ;
Fan, Yong ;
Lu, Lingfei ;
Liu, Lu ;
Fan, Lingling ;
Zhao, Mengyao ;
Xie, Yang ;
Xu, Congjian ;
Zhang, Fan .
NATURE COMMUNICATIONS, 2018, 9
123456