Research progress of Streptococcus pneumoniae capsular polysaccharide-protein conjugate vaccines

被引：1
作者：
Long, Yayi [1 ]
Hou, Yuanyuan [2 ]
Feng, Xue [1 ]
Yang, Dong [2 ]
Ding, Chao [1 ]
Zhen, Yuhong [1 ]
机构：
[1] Dalian Med Univ, Coll Pharm, Dalian, Peoples R China
[2] Dalian Med Univ, Clin Med Year Programme 7, Dalian, Peoples R China
来源：
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2012年 / 6卷 / 07期
关键词：
Conjugate vaccine; Streptococcus pneumoniae; capsular polysaccharide; carrier protein; PNEUMOCOCCAL VIRULENCE PROTEINS; ANTIBODY-RESPONSE; CRM197; CONJUGATE; FILIPINO INFANTS; ISRAELI INFANTS; CARRIER PROTEIN; MURINE MODEL; A PSPA; IMMUNOGENICITY; PNEUMOLYSIN;
D O I：
10.5897/AJMR11.1600
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Streptococcus pneumoniae is a major respiratory pathogen responsible for many diseases in young children and elderly. Because of the increasing antibiotic resistance of pneumococci recently, the need for development of an effective vaccine is more and more urgent. Since the 7-valent conjugate vaccine was licensed in the United States in 2000, its efficacy has been widely recognized. Effort on researching polysaccharide-protein conjugate vaccine never stopped. This article reviewed the conjugate vaccines in view of the carrier proteins.
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页码：1364 / 1369
页数：6
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