Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines

被引：60

作者：

Samshuddin, Seranthimata ^{[1
]}

Narayana, Badiadka ^{[1
]}

Sarojini, Balladka Kunhanna ^{[2
]}

Khan, Mahmud Tareq Hassan

Yathirajan, Hemmige S. ^{[3
]}

Raj, Chenna Govindaraju Darshan ^{[2
]}

Raghavendra, Ramappa ^{[4
]}

机构：

[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India

[2] PA Coll Engn, Dept Chem Res, Mangalore 574153, Karnataka, India

[3] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

[4] Kuvempu Univ, Dept Postgrad Studies & Res Biochem, Shimoga, Karnataka, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期

关键词：

Analgesic; Antimicrobial; DPPH scavenging assay; 1,3,5-Triaryl-2-pyrazoline; Molecular docking; metRS; Molecular recognition; FORCE FIELD; CONFORMATIONAL ENERGIES; PYRAZOLINE DERIVATIVES; MMFF94; GEOMETRIES; 2-PYRAZOLINES; PREDICTION; INHIBITORS; PROTEINS; AGENTS;

D O I：

10.1007/s00044-011-9735-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1,3,5-triaryl-2-pyrazolines 2a-g were synthesized by the reaction of 4,4'-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl-tRNA synthetase (metRS). Some of the tested compounds exhibited significant antimicrobial, analgesic, DPPH scavenging activities and molecular binding.

引用

页码：2012 / 2022

页数：11

共 56 条

[1] ICM - A NEW METHOD FOR PROTEIN MODELING AND DESIGN - APPLICATIONS TO DOCKING AND STRUCTURE PREDICTION FROM THE DISTORTED NATIVE CONFORMATION [J].

ABAGYAN, R ;

TOTROV, M ;

KUZNETSOV, D .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1994, 15 (05) :488-506

[2]

Amir M, 2005, INDIAN J CHEM B, V44, P2532

[3] Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents [J].

Amir, Mohammad ;

Kumar, Harish ;

Khan, Suroor A. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (03) :918-922

[4]

Ankhiwala MD, 1996, INDIAN J HETEROCY CH, V5, P229

[5] Microwave-assisted synthesis of some 3,5-arylated 2-pyrazolines [J].

Azarifar, D ;

Ghasemnejad, H .

MOLECULES, 2003, 8 (08) :642-648

[6]

Bagavant G., 1994, Indian Journal of Pharmaceutical Sciences, V56, P80

[7] 3,5-Bis(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole [J].

Baktir, Zeliha ;

Akkurt, Mehmet ;

Samshuddin, S. ;

Narayana, B. ;

Yathirajan, H. S. .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 :O328-U295

[8] 3,5-Bis(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole [J].

Butcher, Ray J. ;

Akkurt, Mehmet ;

Samshuddin, S. ;

Narayana, B. ;

Yathirajan, H. S. .

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2011, 67 :O1019-U1765

[9] 1-[3,5-Bis(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone [J].

Fun, Hoong-Kun ;

Hemamalini, Madhukar ;

Samshuddin, S. ;

Narayana, B. ;

Yathirajan, H. S. .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 :O582-U4734

[10] Recent Advances in the Synthesis of Pyrazoles. A Review [J].

Fustero, Santos ;

Simon-Fuentes, Antonio ;

Sanz-Cervera, Juan F. .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2009, 41 (04) :253-290

← 1 2 3 4 5 6 →