Unraveling the Anticancer Effect of Curcumin and Resveratrol

被引：87

作者：

Pavan, Aline Renata ^{[1
]}

Bernardes da Silva, Gabriel Dalio ^{[1
]}

Jornada, Daniela Hartmann ^{[1
]}

Chiba, Diego Eidy ^{[1
]}

dos Santos Fernandes, Guilherme Felipe ^{[1
]}

Chin, Chung Man ^{[1
]}

dos Santos, Jean Leandro ^{[1
]}

机构：

[1] UNESP Univ Estadual Paulista, Sch Pharmaceut Sci, BR-14800903 Araraquara, Brazil

来源：

NUTRIENTS | 2016年 / 8卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

cancer; resveratrol; curcumin; polyphenols; anticancer; BREAST-CANCER CELLS; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED MATRIX-METALLOPROTEINASE-9 EXPRESSION; MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; INFLAMMATORY CYTOKINES CXCL1; CATENIN SIGNALING PATHWAY; LUNG ADENOCARCINOMA CELLS; ENDOTHELIAL GROWTH-FACTOR; INHIBITS TUMOR-GROWTH;

D O I：

10.3390/nu8110628

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.

引用

页数：50

共 450 条

[61]

Chen A, 2006, ONCOGENE, V25, P278, DOI [10.1038/sj.onc.1209019, 10.1038/sj.onc.1209573]

[62] Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression [J].

Chen, Bin ;

Zhang, Youzhi ;

Wang, Yang ;

Rao, Jun ;

Jiang, Xiaomei ;

Xu, Zihui .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 143 :11-18

[63] Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class histone deacetylases [J].

Chen, Chi-qi ;

Yu, Kang ;

Yan, Qing-xian ;

Xing, Chong-yun ;

YiChen ;

Yan, Zhuang ;

Shi, Yi-fen ;

Zhao, Ke-Wen ;

Gao, Shen-meng .

CARCINOGENESIS, 2013, 34 (07) :1442-1449

[64] Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1 [J].

Chen, Huei-Wen ;

Lee, Jen-Yi ;

Huang, Ji-Ying ;

Wang, Chi-Chung ;

Chen, Wan-Jiun ;

Su, Sheng-Fang ;

Huang, Chia-Wen ;

Ho, Chao-Chi ;

Chen, Jeremy J. W. ;

Tsai, Meng-Feng ;

Yu, Sung-Liang ;

Yang, Pan-Chyr .

CANCER RESEARCH, 2008, 68 (18) :7428-7438

[65] Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells [J].

Chen, Jie ;

Wang, Guiying ;

Wang, Libing ;

Kang, Jiuhong ;

Wang, Jianmin .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 41 (02) :210-218

[66] Inhibition of tumor growth and vasculogenic mimicry by cucumin through downregulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model [J].

Chen, Lu-Xia ;

He, Yan-Jin ;

Zhao, Shao-Zhen ;

Wu, Jian-Guo ;

Wang, Jian-Tao ;

Zhu, Li-Min ;

Lin, Ting-Ting ;

Sun, Bao-Cun ;

Li, Xiao-Rong .

CANCER BIOLOGY & THERAPY, 2011, 11 (02) :229-235

[67] Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model [J].

Chen, Man-Chin ;

Chang, Wen-Wei ;

Kuan, Yu-Diao ;

Lin, Song-Tao ;

Hsu, Hui-Chun ;

Lee, Che-Hsin .

INNATE IMMUNITY, 2012, 18 (05) :685-693

[68] Curcumin suppresses migration and invasion of human endometrial carcinoma cells [J].

Chen, Qian ;

Gao, Qing ;

Chen, Kunlun ;

Wang, Yidong ;

Chen, Lijuan ;

Li, Xu .

ONCOLOGY LETTERS, 2015, 10 (03) :1297-1302

[69] Curcumin inhibits proliferation-migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1 [J].

Chen, Qing-yong ;

Jiao, De-min ;

Wang, Li-feng ;

Wang, Lishan ;

Hu, Hui-zhen ;

Song, Jia ;

Yan, Jie ;

Wu, Li-jun ;

Shi, Jian-guo .

MOLECULAR BIOSYSTEMS, 2015, 11 (03) :859-868

[70] Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway [J].

Chen, Qing-yong ;

Zheng, Ying ;

Jiao, De-min ;

Chen, Fang-yuan ;

Hu, Hui-zhen ;

Wu, Yu-quan ;

Song, Jia ;

Yan, Jie ;

Wu, Li-jun ;

Lv, Gui-yuan .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2014, 25 (02) :177-185

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