Immunotherapy for the Treatment of Glioblastoma

被引：67
作者：
Thomas, Alissa A. [2 ]
Ernstoff, Marc S. [3 ,4 ]
Fadul, Camilo E. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Dartmouth Hitchcock Med Ctr, Dept Med, Hematol Oncol Sect, Lebanon, NH 03756 USA
[2] Dartmouth Med Sch, Dept Neurol, Lebanon, NH USA
[3] Dartmouth Med Sch, Hematol Oncol Sect, Dept Med, Lebanon, NH USA
[4] Dartmouth Med Sch, Med Oncol Immunotherapy Program, Lebanon, NH USA
[5] Dartmouth Med Sch, Norris Cotton Canc Ctr, Neurooncol Program, Lebanon, NH USA
来源：
CANCER JOURNAL | 2012年 / 18卷 / 01期
关键词：
Glioblastoma; vaccine; immunotherapy; high-grade glioma; RECURRENT MALIGNANT GLIOMAS; ACTIVATED KILLER-CELLS; CENTRAL-NERVOUS-SYSTEM; HIGH-GRADE GLIOMAS; ADOPTIVE CELLULAR IMMUNOTHERAPY; GENE TRANSFECTED FIBROBLASTS; NEWLY-DIAGNOSED GLIOBLASTOMA; IMMUNOREGULATORY T-CELLS; I CLINICAL-TRIAL; PHASE-I/II TRIAL;
D O I：
10.1097/PPO.0b013e3182431a73
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma, the most aggressive primary brain tumor, thrives in a microenvironment of relative immunosuppression within the relatively immune-privileged central nervous system. Despite treatments with surgery, radiation therapy, and chemotherapy, prognosis remains poor. The recent success of immunotherapy in the treatment of other cancers has renewed interest in vaccine therapy for the treatment of gliomas. In this article, we outline various immunotherapeutic strategies, review recent clinical trials data, and discuss the future of vaccine therapy for glioblastoma.
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收藏
页码：59 / 68
页数：10
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