Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis

被引：44
作者：
Ekelund, E.
Saaf, A.
Tengvall-Linder, M.
Melen, E.
Link, J.
Barker, J.
Reynolds, N. J.
Meggitt, S. J.
Kere, J.
Wahlgren, C. -F.
Pershagen, G.
Wickman, M.
Nordenskjold, M.
Kockum, I.
Bradley, M.
机构：
[1] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[2] Karolinska Inst, Dermatol Unit, Stockholm, Sweden
[3] Karolinska Inst, Dept Med, Stockholm, Sweden
[4] Karolinska Inst, Inst Environm Med, Stockholm, Sweden
[5] Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden
[6] Karolinska Inst, Dept Biosci, Stockholm, Sweden
[7] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[8] Stockholm Cty Council, Dept Occupat & Environm Hlth, Stockholm, Sweden
[9] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
[10] Univ London Kings Coll, St Johns Inst Dermatol, London WC2R 2LS, England
[11] Univ Newcastle Upon Tyne, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[12] Royal Victoria Infirm, Dept Dermatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 2006年 / 78卷 / 06期
关键词：
D O I：
10.1086/504272
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P < .02 and P < .03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
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页码：1060 / 1065
页数：6
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