Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis

被引：44

作者：

Ekelund, E.

Saaf, A.

Tengvall-Linder, M.

Melen, E.

Link, J.

Barker, J.

Reynolds, N. J.

Meggitt, S. J.

Kere, J.

Wahlgren, C. -F.

Pershagen, G.

Wickman, M.

Nordenskjold, M.

Kockum, I.

Bradley, M.

机构：

[1] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

[2] Karolinska Inst, Dermatol Unit, Stockholm, Sweden

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[5] Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden

[6] Karolinska Inst, Dept Biosci, Stockholm, Sweden

[7] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[8] Stockholm Cty Council, Dept Occupat & Environm Hlth, Stockholm, Sweden

[9] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[10] Univ London Kings Coll, St Johns Inst Dermatol, London WC2R 2LS, England

[11] Univ Newcastle Upon Tyne, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[12] Royal Victoria Infirm, Dept Dermatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2006年 / 78卷 / 06期

关键词：

D O I：

10.1086/504272

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P < .02 and P < .03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.

引用

页码：1060 / 1065

页数：6

共 22 条

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