Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors

被引：72

作者：

Guan, Ronggui ^{[1
]}

Xu, Xiaoyu ^{[1
]}

Chen, Meihui ^{[1
]}

Hu, Haiyan ^{[1
]}

Ge, Hu ^{[1
]}

Wen, Shijun ^{[2
]}

Zhou, Shiyou ^{[3
]}

Pi, Rongbiao ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 70卷

基金：

中国国家自然科学基金;

关键词：

RhoA; Rho kinase; Inhibitors; Central nervous system; Fasudil; CENTRAL-NERVOUS-SYSTEM; RHO-ASSOCIATED KINASE; ROCK INHIBITORS; THERAPEUTIC TARGET; FASUDIL; DISCOVERY; POTENT; OPTIMIZATION; DERIVATIVES; 7-AZAINDOLES;

D O I：

10.1016/j.ejmech.2013.10.048

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

RhoA/Rho-kinase pathway plays a pivotal role in numerous fundamental cellular functions including contraction, motility, proliferation, differentiation and apoptosis. The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous systems (CNS) disorders. The inhibitors of Rho kinase have been extensively studied since the Rho/Rho-kinase pathway was verified as a target for a number of diseases. Herein, we reviewed the advances in the studies of the roles of Rho/Rho-kinase in diseases and the development of Rho-kinase inhibitors in recent five years. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：613 / 622

页数：10