Coexisting cancers: a mixture of neuroendocrine carcinoma and adenocarcinoma in the gallbladder A case report

被引：5

作者：

Hu, Hai-Jie ^{[1
]}

Zhou, Rong-Xing ^{[1
]}

Tan, Yong-Qiong ^{[1
]}

Jing, Qiu-Yang ^{[2
]}

Ma, Wen-Jie ^{[1
]}

Yang, Qin ^{[1
]}

Wang, Jun-Ke ^{[1
]}

Wang, Shu-Jin ^{[1
]}

Cheng, Nan-Sheng ^{[1
]}

Li, Fu-Yu ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Billary Surg, Chengdu 610041, Sichuan Provinc, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu, Sichuan Provinc, Peoples R China

来源：

MEDICINE | 2016年 / 95卷 / 44期

关键词：

adenocarcinoma; gallbladder; multimodal treatment; neuroendocrine; CELL-CARCINOMA; TUMORS;

D O I：

10.1097/MD.0000000000005281

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Neuroendocrine carcinoma is rare with a proportion of less than 2% in gallbladder malignancies, cases of gallbladder neuroendocrine cell carcinoma coexisting with adenocarcinoma are exceptionally rare, and the prognosis is dismal. Methods: Herein, we presented an unusual case of poorly differentiated gallbladder neuroendocrine cell carcinoma coexisting with poorly differentiated adenocarcinoma who survived 20 months after the multimodal treatment (MT) of extended surgery and postoperative chemotherapy. Results: Our result indicated that for advanced gallbladder neuroendocrine cell carcinoma coexisting with adenocarcinoma, MT including extended surgical approach combined with postoperative chemotherapy may contribute to a relatively good survival outcome. Conclusion: MT may contribute to a relatively good survival outcome for advanced gallbladder neuroendocrine cell carcinoma coexisting with gallbladder adenocarcinoma.

引用

页数：3

共 11 条

[1] Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program [J].

Albores-Saavedra, Jorge ;

Batich, Kristen ;

Hossain, Sarah ;

Henson, Donald E. ;

Schwartz, Arnold M. .

ANNALS OF DIAGNOSTIC PATHOLOGY, 2009, 13 (06) :378-383

[2] Two cases of neuroendocrine carcinoma of the gallbladder [J].

Chen, Hao ;

Shen, Yan-Ying ;

Ni, Xing-Zhi .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (33) :11916-11920

[3] Neuroendocrine Tumors of the Gallbladder An Evaluation and Reassessment of Management Strategy [J].

Eltawil, Karim M. ;

Gustafsson, Bjorn I. ;

Kidd, Mark ;

Modlin, Irvin M. .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2010, 44 (10) :687-695

[4]

Kim DI, 2011, TUMORI, V97, P815, DOI 10.1700/1018.11103

[5] The Pathologic Classification of Neuroendocrine Tumors A Review of Nomenclature, Grading, and Staging Systems [J].

Klimstra, David S. ;

Modlin, Irvin R. ;

Coppola, Domenico ;

Lloyd, Ricardo V. ;

Suster, Saul .

PANCREAS, 2010, 39 (06) :707-712

[6] The gastroenteropancreatic neuroendocrine cell system and its tumors [J].

Klöppel, G ;

Perren, A ;

Heitz, PU .

GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR DISEASE: MOLECULAR AND CELL BIOLOGICAL ASPECTS, 2004, 1014 :13-27

[7] Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature [J].

Liu, Wei ;

Wang, Lei ;

He, Xiao-dong ;

Feng, Cheng ;

Chang, Xiao-yan ;

Lu, Zhao-hui .

WORLD JOURNAL OF SURGICAL ONCOLOGY, 2015, 13

[8] A 5-decade analysis of 13,715 carcinoid tumors [J].

Modlin, IM ;

Lye, KD ;

Kidd, M .

CANCER, 2003, 97 (04) :934-959

[9]

Shimizu Tetsuya, 2006, Journal of Nippon Medical School, V73, P101, DOI 10.1272/jnms.73.101

[10] Adenoendocrine cell carcinoma of the gallbladder: Report of a case [J].

Tsuchiya, Atsuo ;

Endo, Yoshiyuki ;

Yazawa, Takashi ;

Saito, Atsuko ;

Inoue, Norio .

SURGERY TODAY, 2006, 36 (09) :849-852

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