Ectoine as a promising protective agent in humans and animals

被引：72
作者：
Bownik, Adam [1 ]
Stepniewska, Zofia [2 ]
机构：
[1] Univ Life Sci Lublin, Dept Biol Basis Anim Prod, Fac Biol Anim Sci & Bioecon, Akad 13 Str, PL-20950 Lublin, Poland
[2] John Paul II Catholic Univ Lublin, Dept Biochem & Environm Chem, Fac Biotechnol & Environm Sci, Lublin, Poland
来源：
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY | 2016年 / 67卷 / 04期
关键词：
cell protection; compatible solute; macromolecular stability; osmoprotectant; COMPATIBLE SOLUTE ECTOINE; NATURAL TETRAHYDROPYRIMIDINE; PREFERENTIAL EXCLUSION; BIOCHEMICAL PARAMETERS; INHIBIT AGGREGATION; BINDING; STABILIZATION; NEUROTOXICITY; STABILITY; HYDRATION;
D O I：
10.1515/aiht-2016-67-2837
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Ectoine is a compatible water molecule-binding solute (osmoprotectant) produced by several bacterial species in response to osmotic stress and unfavourable environmental conditions. This amino acid derivative can accumulate inside cells at high concentrations without interfering with natural processes and can protect the cell against radiation or osmotic stress. This brief review presents the current state of knowledge about the effects of ectoine on animals and focuses on its practical use for enzyme stabilisation, human skin protection, anti-inflammatory treatment, inhibitory effects in neurodegenerative diseases, and other therapeutic potential in human or veterinary medicine.
引用
收藏
页码：260 / 265
页数：6
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