Ectoine as a promising protective agent in humans and animals

被引：70
作者：
Bownik, Adam [1 ]
Stepniewska, Zofia [2 ]
机构：
[1] Univ Life Sci Lublin, Dept Biol Basis Anim Prod, Fac Biol Anim Sci & Bioecon, Akad 13 Str, PL-20950 Lublin, Poland
[2] John Paul II Catholic Univ Lublin, Dept Biochem & Environm Chem, Fac Biotechnol & Environm Sci, Lublin, Poland
来源：
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY | 2016年 / 67卷 / 04期
关键词：
cell protection; compatible solute; macromolecular stability; osmoprotectant; COMPATIBLE SOLUTE ECTOINE; NATURAL TETRAHYDROPYRIMIDINE; PREFERENTIAL EXCLUSION; BIOCHEMICAL PARAMETERS; INHIBIT AGGREGATION; BINDING; STABILIZATION; NEUROTOXICITY; STABILITY; HYDRATION;
D O I：
10.1515/aiht-2016-67-2837
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Ectoine is a compatible water molecule-binding solute (osmoprotectant) produced by several bacterial species in response to osmotic stress and unfavourable environmental conditions. This amino acid derivative can accumulate inside cells at high concentrations without interfering with natural processes and can protect the cell against radiation or osmotic stress. This brief review presents the current state of knowledge about the effects of ectoine on animals and focuses on its practical use for enzyme stabilisation, human skin protection, anti-inflammatory treatment, inhibitory effects in neurodegenerative diseases, and other therapeutic potential in human or veterinary medicine.
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收藏
页码：260 / 265
页数：6
相关论文
共 56 条
  • [1] Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis
    Abdel-Aziz, Heba
    Wadie, Walaa
    Abdallah, Dalaal M.
    Lentzen, Georg
    Khayyal, Mohamed T.
    [J]. PHYTOMEDICINE, 2013, 20 (07) : 585 - 591
  • [2] Mammalian prion biology: One century of evolving concepts
    Aguzzi, A
    Polymenidou, M
    [J]. CELL, 2004, 116 (02) : 313 - 327
  • [3] THE STABILIZATION OF PROTEINS BY OSMOLYTES
    ARAKAWA, T
    TIMASHEFF, SN
    [J]. BIOPHYSICAL JOURNAL, 1985, 47 (03) : 411 - 414
  • [4] Inhibition of insulin amyloid formation by small stress molecules
    Arora, A
    Ha, C
    Park, CB
    [J]. FEBS LETTERS, 2004, 564 (1-2) : 121 - 125
  • [5] Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine
    Becker, Judith
    Schaefer, Rudolf
    Kohlstedt, Michael
    Harder, Bjoern J.
    Borchert, Nicole S.
    Stoeveken, Nadine
    Bremer, Erhard
    Wittmann, Christoph
    [J]. MICROBIAL CELL FACTORIES, 2013, 12
  • [6] Bersch S, 2000, PROTECTION ANTIBODIE
  • [7] Bissoyi A, 2014, CRYOLETT, V34, P453
  • [8] Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens
    Botta, Celine
    Di Giorgio, Carole
    Sabatier, Anne-Sophie
    De Meo, Michel
    [J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2008, 91 (01) : 24 - 34
  • [9] Bownik A., 2014, J COMP PHYSIOL B, V184, P961, DOI DOI 10.1007/S00360-014-0860-X
  • [10] Ectoine alleviates behavioural, physiological and biochemical changes in Daphnia magna subjected to formaldehyde
    Bownik, Adam
    Stepniewska, Zofia
    [J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2015, 22 (20) : 15549 - 15562
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