Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study

被引：11

作者：

Emanuel, Lengwiler ^{[1
]}

Susanne, Stampf ^{[2
]}

Alfred, Zippelius ^{[3
]}

Emanuelle, Salati ^{[4
]}

Khalil, Zaman ^{[5
]}

Niklaus, Schafer ^{[6
]}

Julian, Schardt ^{[7
]}

Marco, Siano ^{[8
]}

Gunther, Hofbauer F. L. ^{[1
]}

Rita, Achermann

Patrizia, Amico

John-David, Aubert

Vanessa, Banz

Guido, Beldi

Christian, Benden

Christoph, Berger

Isabelle, Binet

Pierre-Yves, Bochud

Heiner, Bucher

Leo, Buhler

Thierry, Carell

Emmanuelle, Catana

Yves, Chalandon

Sabina, De Geest

Olivier, De Rougemont

Michael, Dickenmann

Michel, Duchosal

Laure, Elkrief

Thomas, Fehr

Sylvie, Ferrari-Lacraz

Christian, Garzoni

Paola, Gasche Soccal

Christophe, Gaudet

Emiliano, Giostra

Dela, Golshayan

Karine, Hadaya

Jorg, Halter

Dominik, Heim

Christoph, Hess

Sven, Hillinger

Hans, Hirsch H.

Gunther, Hofbauer

Uyen, Huynh-Do

Franz, Immer

Richard, Klaghofer

Michael, Koller

Bettina, Laesser

Roger, Lehmann

Christian, Lovis

Oriol, Manuel

机构：

[1] Univ Hosp Zurich, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland

[2] Univ Hosp Basel, Clin Transplantat Immunol & Nephrol, Basel, Switzerland

[3] Univ Hosp Basel, Dept Biomed, Basel, Switzerland

[4] Univ Hosp Geneva, Div Oncol, Geneva, Switzerland

[5] Univ Hosp Lausanne, Dept Oncol, Lausanne, Switzerland

[6] Inselspital Hosp Lausanne, Div Oncol, Lausanne, Switzerland

[7] Univ Bern, Div Oncol, Bern, Switzerland

[8] Cantonal Hosp St Gallen, Div Oncol, St Gallen, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2019年 / 149卷

关键词：

solid organ transplantation; cancer; kidney transplantation; heart transplantation; liver transplantation; lung transplantation; pancreas transplantation; non-cutaneous malignancies; immunosuppression; BRONCHOGENIC-CARCINOMA; RENAL-TRANSPLANTATION; RISK; MALIGNANCIES;

D O I：

10.4414/smw.2019.20078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In solid organ transplant recipients (sOTRs), 5 years after transplantation cancer is a relevant cause of death. We aimed to report cancer incidence in the Swiss Transplant Cohort Study (STCS) between 2008 and 2014 and conducted a prospective cohort study of kidney, heart, lung, pancreas and liver transplant recipients enrolled into the STCS by retrospective analysis of collected data. The STCS provided data on 2758 solid organ transplants. In total, 134 cases of cancer were observed (30 liver, 21 prostate, 18 lung, 13 kidney, 52 other cancers). Standardised incidence ratios (SIRs) were highest for liver cancer, kidney cancer, thyroid cancer, gastric cancer, bladder cancer, cancer of the oral cavity and the pharynx and for lung cancer. Cancer occurrence differed according to the transplanted organ. Cancers were mainly diagnosed at World Health Organisation (WHO) stages I and IV. Treatment received was mainly surgery and, in some cases, included also radiation and/or chemotherapy. Bladder, kidney, liver, lung and prostate cancer were detected at a younger age compared with the general population. Cumulative hazards for death were increased for transplant recipients with cancer. Solid organ transplant recipients show an organ specific increase of cancer compared with the general Swiss population.

引用

页数：9

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