Surveillance of Antibiotic Resistance Genes in Treponema Pallidum Subspecies Pallidum from Patients with Early Syphilis in France

被引：20

作者：

Sanchez, Adrien ^{[1
,2
]}

Mayslich, Constance ^{[1
]}

Malet, Isabelle ^{[3
]}

Grange, Philippe Alain ^{[1
]}

Janier, Michel ^{[4
]}

Saule, Julie ^{[5
]}

Martinet, Pervenche ^{[6
]}

Robert, Jean-Luc ^{[6
]}

Moulene, Dominique ^{[7
]}

Truchetet, Francois ^{[8
]}

Pinault, Anne-Lise ^{[9
]}

Vermersch-Langlin, Annie ^{[10
]}

Benhaddou, Nadjet ^{[1
,11
]}

Chanal, Johan ^{[2
]}

Dupin, Nicolas ^{[1
,2
]}

机构：

[1] Sorbonne Paris Descartes Univ, Cochin Inst, INSERM, CNRS,UMR8104,U1016, Paris, France

[2] CNR IST Bacteriennes Syphilis, Dept Dermatovenerol, APHP Hosp Grp Paris Ctr Cochin Hotel Dieu Broca, Paris, France

[3] UPMC Univ Paris 06, Pierre Louis Insitute Epidemiol & Publ Hlth IPLES, Sorbonne Univ, Dept Virol,APHP Hop Pitie Salpetriere,INSERM, Paris, France

[4] Hosp Grp St Louis Lariboisiere Fernand Widal, AP HP, CeGIDD, Paris, France

[5] CeGIDD La Joliette CD13, Marseille, France

[6] CeGIDD St Adrien CD13, Marseille, France

[7] CeGIDD Aix En Provence CD13, Aix En Provence, France

[8] CHR Metz Thionville, Dept Dermatol, Bel Air Hosp, Metz, France

[9] CeGIDD Nancy, Nancy, France

[10] Jean Bernard Hosp, Dept Dermatol, Valenciennes, France

[11] Hosp Grp Paris Ctr Cochin Hotel Dieu Broca, AP HP, Dept Bacteriol CNR Streptocoques, Paris, France

来源：

ACTA DERMATO-VENEREOLOGICA | 2020年 / 100卷

关键词：

syphilis; Treponema pallidum subs pallidum; antibiotic resistance; doxycycline; macrolide; 16S RIBOSOMAL-RNA; SEXUALLY-TRANSMITTED INFECTIONS; TETRACYCLINE-RESISTANCE; PREEXPOSURE PROPHYLAXIS; MACROLIDE RESISTANCE; EUROPEAN GUIDELINE; UNITED-STATES; HIGH-RISK; MUTATIONS; DOXYCYCLINE;

D O I：

10.2340/00015555-3589

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Benzathine penicillin G (BPG) is the reference treatment for early syphilis, but shortages have recently been reported, highlighting a need for the validation of alternative treatments. The aim of this study was to evaluate the genomic resistance of Treponema pallidum subspecies pallidum (TPA) to macrolides and doxycycline in France. Swabs from genital, anal, oral and cutaneous lesions were obtained from 146 patients with early syphilis in France. They were screened for mutations conferring resistance to macrolides and doxycycline by nested PCR and sequencing. Resistance to macrolides was detected in 85% of the isolates, but no point mutations conferring doxycycline resistance were detected. These findings confirm that, in France, resistance to macrolides is widespread. Moreover, we confirmed the absence of genomic resistance to doxycycline in the TPA strains. Therefore, doxycycline could be safely recommended as an alternative to BPG for the treatment of early syphilis.

引用

页码：1 / 5

页数：5

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