Melanocytoma of the optic disk: A review

被引:57
作者
Shields, JA
Demirci, H
Mashayekhi, A
Eagle, RC
Shields, CL
机构
[1] Thomas Jefferson Univ, Wills Eye Hosp, Oncol Serv, Philadelphia, PA USA
[2] Thomas Jefferson Univ, Wills Eye Hosp, Dept Pathol, Philadelphia, PA USA
关键词
choroid; eye; magnocellular nevus; melanocytoma; melanoma; optic disk; optic nerve; psendomelanoma; retina; tumor; uvea; uveal tract;
D O I
10.1016/j.survophthal.2005.12.011
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. Today, however, it is generally recognized by its typical clinical features that differ from most melanomas and erroneous enucleation is rarely done. Histopathologically, melanocytoma is composed of intensely pigmented round to oval nevus cells with benign features. Although traditionally believed to be a relatively stationary lesion, it is now known to exhibit minor enlargement in 10-15% of cases and call cause minor visual loss by a variety of mechanisms. In rare instance, it can induce severe visual loss due to spontaneous necrosis of the lesion or compressive optic neuropathy. More importantly, it can exhibit malignant transformation into melanoma in 1-2% of cases. Ophthalmologists should be familiar with melanocytoma of the optic disk and affected patients should be followed periodically.
引用
收藏
页码:93 / 104
页数:12
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