IFNγ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages

被引：132
作者：
Bautista, EM [1 ]
Molitor, TW [1 ]
机构：
[1] Univ Minnesota, Coll Vet Med, Dept Clin & Populat Sci, St Paul, MN 55108 USA
来源：
ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 06期
关键词：
D O I：
10.1007/s007050050578
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study reports the effect of IFN gamma on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFN gamma profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFN gamma on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFN gamma may play an important role in protection.
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收藏
页码：1191 / 1200
页数：10
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