Usefulness of preoperative lymphoscintigraphy in patients who undergo radical hysterectomy and pelvic lymphadenectomy for cervical cancer

被引:29
作者
Frumovitz, M
Coleman, RL
Gayed, IW
Ramirez, PT
Wolf, JK
Gershenson, DM
Levenback, CF
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Unit 1362, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Nucl Med, Houston, TX 77030 USA
关键词
cervical cancer; sentinel lymph node; intraoperative lymphatic mapping; lymphoscintigraphy;
D O I
10.1016/j.ajog.2005.12.018
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The purpose of this study was to assess the value of preoperative lymphoscintigraphy before intraoperative lymphatic mapping for sentinel lymph node identification during radical hysterectomy. Study design: Fifty patients underwent intraoperative lymphatic mapping on our institutional review board-approved protocol. The location of sentinel lymph nodes that were found on lymphoscintigraphy and intraoperative lymphatic mapping were compared. Results: Fifteen of 21 patients (71%) with solitary sentinel lymph nodes that were found on lymphoscintigraphy had multiple sentinel lymph node basins found during the operation. Thirteen of 25 patients (52%) with unilateral sentinel lymph node basins that were found on lymphoscintigraphy had bilateral sentinel lymph nodes at intraoperative lymphatic mapping. Of 15 patients with 2 sentinel lymph node locations that were identified on lymphoscintigraphy, 12 patients (80%) had >= 3 found during the operation. Of the sentinel lymph nodes that were located on the external iliac basin (n = 47) on lymphoscintigraphy, only 20 lymph nodes (43%.) were found at that location during the operation. Concordance between the 2 methods was poor. Seven of the 9 patients with lymph node metastases had disease that was limited to the sentinel lymph nodes. Conclusion: Preoperative lymphoscintigraphy adds little value over intraoperative lymphatic mapping for sentinel lymph node identification during radical hysterectomy. (C) 2006 Mosby, Inc. All rights reserved.
引用
收藏
页码:1186 / 1193
页数:8
相关论文
共 19 条
  • [1] A randomized study comparing retroperitoneal drainage with no drainage after lymphadenectomy in gynecologic malignancies
    BenedettiPanici, P
    Maneschi, F
    Cutillo, G
    DAndrea, G
    diPalumbo, VS
    Conte, M
    Scambia, G
    Mancuso, S
    [J]. GYNECOLOGIC ONCOLOGY, 1997, 65 (03) : 478 - 482
  • [2] Burke, 1994, Semin Radiat Oncol, V4, P34, DOI 10.1016/S1053-4296(05)80108-0
  • [3] Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva
    de Hullu, JA
    Hollema, H
    Piers, DA
    Verheijen, RHM
    van Diest, PJ
    Mourits, MJE
    Aalders, JG
    van der Zee, AGJ
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (15) : 2811 - 2816
  • [4] Even-Sapir E, 2003, J NUCL MED, V44, P1413
  • [5] Total laparoscopic radical hysterectomy with intraoperative sentinel node identification in patients with early invasive cervical cancer
    Gil-Moreno, A
    Díaz-Feijoo, B
    Roca, I
    Puig, O
    Pérez-Benavente, MA
    Aguilar, I
    Martínez-Palones, JM
    Xercavins, J
    [J]. GYNECOLOGIC ONCOLOGY, 2005, 96 (01) : 187 - 193
  • [6] Lymphatic mapping and sentinel lymphadenectomy for breast cancer
    Kelley, MC
    Hansen, N
    McMasters, KM
    [J]. AMERICAN JOURNAL OF SURGERY, 2004, 188 (01) : 49 - 61
  • [7] Intraoperative lymphatic mapping and sentinel node identification with blue dye in patients with vulvar cancer
    Levenback, C
    Coleman, RL
    Burke, TW
    Bodurka-Bevers, D
    Wolf, JK
    Gershenson, DM
    [J]. GYNECOLOGIC ONCOLOGY, 2001, 83 (02) : 276 - 281
  • [8] Lymphatic mapping and sentinel node identification in patients with cervix cancer undergoing radical hysterectomy and pelvic lymphadenectomy
    Levenback, C
    Coleman, RL
    Burke, TW
    Lin, WM
    Erdman, W
    Deavers, M
    Delpassand, ES
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (03) : 688 - 693
  • [9] Use of tomographic nuclear medicine procedures, SPECT and pinhole SPECT, with cationic lipophilic radiotracers for the evaluation of axillary lymph node status in breast cancer patients
    Madeddu, G
    Spanu, A
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (Suppl 1) : S23 - S34
  • [10] Sentinel lymph node biopsy is not accurate in predicting lymph node status for patients with cervical carcinoma
    Marchiolè, P
    Buénerd, A
    Scoazec, JY
    Dargent, D
    Mathevet, P
    [J]. CANCER, 2004, 100 (10) : 2154 - 2159