Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae

被引：82

作者：

Bueno, Maria Fernanda C. ^{[1
,2
]}

Francisco, Gabriela R. ^{[1
,2
]}

O'Hara, Jessica A. ^{[2
]}

Garcia, Doroti de Oliveira ^{[1
]}

Doi, Yohei ^{[2
]}

机构：

[1] Adolfo Lutz Inst, Enter Dis & Infect Special Pathogens Lab, Sao Paulo, Brazil

[2] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

HIGH PREVALENCE; ENTEROBACTERIACEAE; RESISTANT; INFECTIONS; EMERGENCE; PLASMIDS; SPREAD; GENES;

D O I：

10.1128/AAC.02108-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eight Klebsiella pneumoniae clinical strains with high-level aminoglycoside resistance were collected from eight hospitals in Sao Paulo State, Brazil, in 2010 and 2011. Three of them produced an RmtD group 16S rRNA methyltransferase, RmtD1 or RmtD2. Five strains were found to produce a novel 16S rRNA methyltransferase, designated RmtG, which shared 57 to 58% amino acid identity with RmtD1 and RmtD2. Seven strains coproduced KPC-2 with or without various CTX-M group extended-spectrum beta-lactamases, while the remaining strain coproduced CTX-M-2.

引用

页码：2397 / 2400

页数：4

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