Menthacarin attenuates experimental colitis

被引：8

作者：

Alliger, Korina ^{[1
]}

Khalil, Mohammad ^{[1
,2
]}

Koenig, Beatrix ^{[3
]}

Weisenburger, Sabrina ^{[3
]}

Koch, Egon ^{[3
]}

Engel, Matthias ^{[1
]}

机构：

[1] Univ Klinikum Erlangen, Dept Med 1, Ulmenweg 18, D-91054 Erlangen, Germany

[2] Inst Physiol & Pathophysiol, Univ Str 17, D-91054 Erlangen, Germany

[3] Dr Willmar Schwabe Pharmaceut, Preclin Res, Willmar Schwabe St 4, D-76227 Karlsruhe, Germany

来源：

PHYTOMEDICINE | 2020年 / 77卷

关键词：

Inflammatory bowel disease; Peppermint; Caraway; Menthacarin; TRPA1; TRPM8; PEPPERMINT OIL; INFLAMMATION; INHIBITION; LIMONENE; DISEASE; ALPHA;

D O I：

10.1016/j.phymed.2020.153212

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Background: Peppermint oil and caraway oil are established remedies in gastroenterological medicine because of their spasmolytic/analgesic effects. Purpose: We investigated whether Menthacarin, a combination of both oils, exerted anti-inflammatory effects in a dextran sodium sulphate (DSS, 2%) murine model of colitis. Study Design and Methods: C57BL/6 mice were orally administered Menthacarin in doses of 10, 30, 60, and 120 mu g/g body weight (BW), and control mice received 0.2% agar, 10 mu l/g BW, during 8 days of DSS-induced colitis. Colitis was monitored by BW measurements and colonoscopies. Colons of euthanised mice were excised for histological staining and ELISA measurements of the cytokines TNF alpha, IL-6, IL-10, IL-1 beta, and TGF-beta. Results: Menthacarin-treated mice compared to controls showed improved macroscopical and microscopical parameters and lower BW loss during the course of colitis. Menthacarin changed the colonic cytokine profile towards a regulatory/anti-inflammatory phenotype. Conclusion: Menthacarin attenuates experimental colitis and may be a promising add-on therapy for the treatment of IBD.

引用

页数：6

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