Effect of phenofibrate therapy on endothelial dysfunction in patients with a history of myocardial infarction in young age

Aim. To evaluate the severity of endothelial dysfunction in patients with a history of myocardial infarction in young age and its changes during therapy with lipantil 200M. Material and methods. The percentage of dilatation of the brachial artery during reactive hyperemia test, number of circulating desquamated endotheliocytes, and lipid metabolism parameters were evaluated in 40 men with a history of myocardial infarction before the age of 45 years and 40 healthy men. Results. Endothelial dysfunction was detected in coronary patients: the percentage of dilatation of the brachial artery was decreased, the number of circulating endotheliocytes increased, and lipid metabolism disordered. After 3-month lipantil 200M therapy the severity of endothelial dysfunction significantly decreased and lipid metabolism parameters improved. Conclusion. Patients with a hislory of in myocardial infarction in young age develop endothelial dysfunction, whose severity decreases after hypolipidemic therapy.