Receptor-dependent regulation of dendrite formation of noradrenaline and dopamine in non-gabaergic cerebral cortical neurons

被引：6

作者：

Li, Fei ^{[1
]}

Ohtani, Akiko ^{[1
]}

Senzaki, Kouji ^{[1
]}

Shiga, Takashi ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058577, Japan

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2013年 / 73卷 / 05期

关键词：

adrenergic receptor; dopamine receptor; cerebral cortex; dendrite formation; primary neuronal culture; MICROTUBULE-ASSOCIATED PROTEIN-2; NEURAL PROGENITOR CELLS; CORTEX IN-VITRO; RAT-BRAIN; PREFRONTAL CORTEX; ADRENERGIC-RECEPTORS; NEURITE OUTGROWTH; STRIATAL NEURONS; GROWTH; DIFFERENTIATION;

D O I：

10.1002/dneu.22065

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present study characterized the receptor-dependent regulation of dendrite formation of noradrenaline (NA) and dopamine (DA) in cultured neurons obtained from embryonic day 16 rat cerebral cortex. Morphological diversity of cortical dendrites was analyzed on various features: dendrite initiation, dendrite outgrowth, and dendrite branching. Using a combination of immunocytochemical markers of dendrites and GABAergic neurons, we focused on the dendrite morphology of non-GABAergic neurons. Our results showed that (1) NA inhibited the dendrite branching, (2) adrenergic receptor (-AR) agonist inhibited the dendrite initiation, while promoted the dendrite outgrowth, (3) 1-AR and 2-AR were present in all the cultured neurons, and both agonists inhibited the dendrite initiation, while only 1-AR agonist induced the dendrite branching; (4) DA inhibited the dendrite outgrowth, (5) D1 receptor agonist inhibited the dendrite initiation, while promoted the dendrite branching. In conclusion, this study compared the effects of NA, DA and their receptors and showed that NA and DA regulate different features on the dendrite formation of non-GABAergic cortical neurons, depending on the receptors. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol 73: 370383, 2013

引用

页码：370 / 383

页数：14

共 63 条

[1] Toward a New Understanding of Attention-Deficit Hyperactivity Disorder Pathophysiology An Important Role for Prefrontal Cortex Dysfunction [J].

Arnsten, Amy F. T. .

CNS DRUGS, 2009, 23 :33-41

[2] Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments [J].

Baj, Gabriele ;

Leone, Emiliano ;

Chao, Moses V. ;

Tongiorgi, Enrico .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (40) :16813-16818

[3] PATTERN OF CELL MIGRATION DURING CORTICAL HISTOGENESIS [J].

BERRY, M ;

EAYRS, JT ;

ROGERS, AW .

NATURE, 1964, 203 (494) :591-&

[4]

Bosco A, 1999, J NEUROSCI RES, V57, P759, DOI 10.1002/(SICI)1097-4547(19990915)57:6<759::AID-JNR1>3.3.CO

[5]

2-P

[6] β-Adrenoceptor Blockers Increase Cardiac Sympathetic Innervation by Inhibiting Autoreceptor Suppression of Axon Growth [J].

Clarke, Gwenaelle L. ;

Bhattacherjee, Aritra ;

Tague, Sarah E. ;

Hasan, Wohaib ;

Smith, Peter G. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (37) :12446-12454

[7] CYCLIC AMP-GENERATING SYSTEMS - REGIONAL DIFFERENCES IN ACTIVATION BY ADRENERGIC-RECEPTORS IN RAT-BRAIN [J].

DALY, JW ;

PADGETT, W ;

CREVELING, CR ;

CANTACUZENE, D ;

KIRK, KL .

JOURNAL OF NEUROSCIENCE, 1981, 1 (01) :49-59

[8]

DeLima AD, 1997, J COMP NEUROL, V382, P230, DOI 10.1002/(SICI)1096-9861(19970602)382:2<230::AID-CNE7>3.0.CO

[9]

2-4

[10] The Molecular and Genetic Mechanisms of Neocortex Development [J].

Diaz, Alejandro L. ;

Gleeson, Joseph G. .

CLINICS IN PERINATOLOGY, 2009, 36 (03) :503-+

← 1 2 3 4 5 6 7 →