Synthesis of Spiro1,4-Dihydropyridines: A Review

被引：4

作者：

Sadri, Zahra ^{[1
]}

Behbahani, Farahnaz K. ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Karaj Branch, Karaj, Iran

来源：

CURRENT ORGANIC SYNTHESIS | 2020年 / 17卷 / 05期

关键词：

Spiro1,4-dihydropyridines; heterocyclic; synthesis; multi-component; one-pot; bronested acids; DEEP EUTECTIC SOLVENT; ONE-POT; EFFICIENT SYNTHESIS; MULTICOMPONENT SYNTHESIS; COMBINATORIAL SYNTHESIS; SPIRO-DIHYDROPYRIDINES; 3-COMPONENT SYNTHESIS; CATALYST; ACID; DERIVATIVES;

D O I：

10.2174/1570179417666200415150027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of medicinally promising spiro1,4-dihydropyridines accompanied by their applications in biological and pharmaceutical activities is presented. Spiro1,4-dihydropyridines were synthesized using numerous reported methods including bronested acids such as p-TSA, AcOH, nano-ranged calix[4]arene tetracarboxylic acid, sulfamic acid, PEG-OSO3H, tetramethylguanidinium triflate; lewis acids including Zn(OTf)(2), FeCl3, copper, alum, aluminosilicate nanoparticles, MnFe2O4 nanoparticles, manganese ferrite nanoparticles, BF3OEt2; under alkaline conditions such as Et3N and piperidine; ionic liquids such as [KAl(SO4)(2)center dot 12H(2)O] and [Bmim]PF6, [MIM(CH2)(4)SO3H][HSO4]; and other miscellaneous procedures, for example, microwave-assisted catalyst and solvent-free conditions, using iodine, PEG-400, and NaCl.

引用

页码：324 / 343

页数：20

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