A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

被引：325

作者：

Andrey, Guillaume ^{[1
]}

Montavon, Thomas ^{[1
]}

Mascrez, Benedicte ^{[2
]}

Gonzalez, Federico ^{[2
]}

Noordermeer, Daan ^{[1
]}

Leleu, Marion ^{[1
]}

Trono, Didier ^{[1
]}

Spitz, Francois ^{[3
]}

Duboule, Denis ^{[1
,2
]}

机构：

[1] Fed Inst Technol, Sch Life Sci, CH-1015 Lausanne, Switzerland

[2] Univ Geneva, Dept Genet & Evolut, Natl Res Ctr Frontiers Genet, CH-1211 Geneva 4, Switzerland

[3] European Mol Biol Lab, Dev Biol Unit, D-69117 Heidelberg, Germany

来源：

SCIENCE | 2013年 / 340卷 / 6137期

基金：

欧洲研究理事会;

关键词：

EMBRYONIC STEM-CELLS; DEVELOPMENTAL REGULATORS; EXPRESSION; MURINE; DROSOPHILA; POLYCOMB; GENOME; DIGITS; ORGANIZATION; MECHANISMS;

D O I：

10.1126/science.1234167

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, and later, when digits form. The transition between early and late regulations involves a functional switch between two opposite topological domains. This switch is reflected by a subset of Hoxd genes mapping centrally into the cluster, which initially interact with the telomeric domain and subsequently swing toward the centromeric domain, where they establish new contacts. This transition between independent regulatory landscapes illustrates both the modularity of the limbs and the distinct evolutionary histories of its various pieces. It also allows the formation of an intermediate area of low HOX proteins content, which develops into the wrist, the transition between our arms and our hands. This regulatory strategy accounts for collinear Hox gene regulation in land vertebrate appendages.

引用

页码：1195 / +

页数：11