RNA polymerase II transcription: Structure and mechanism

被引：105

作者：

Liu, Xin ^{[1
]}

Bushnell, David A. ^{[1
]}

Kornberg, Roger D. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2013年 / 1829卷 / 01期

关键词：

TFIIB; Trigger loop; Bridge helix; Backtracked state; Hybrid helix melting; CORE PROMOTER ELEMENT; TATA-BINDING PROTEIN; C-TERMINAL DOMAIN; DNA-BINDING; CRYSTAL-STRUCTURE; POLYCISTRONIC TRANSCRIPTION; ARCHAEAL TRANSCRIPTION; FACTOR REQUIREMENTS; ELONGATION COMPLEX; ACTIVE-CENTER;

D O I：

10.1016/j.bbagrm.2012.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five general transcription factors (GTFs) TFIIB, -D, -E, -F, and -H. The addition of Mediator enables a response to regulatory factors. The GTFs are required for promoter recognition and the initiation of transcription. Following initiation, pol II alone is capable of RNA transcript elongation and of proofreading. Structural studies reviewed here reveal roles of GTFs in the initiation process and shed light on the transcription elongation mechanism. This article is part of a Special Issue entitled: RNA Polymerase II Transcript Elongation. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：2 / 8

页数：7

共 88 条

[1] Architecture of initiation-competent 12-subunit RNA polymerase II [J].

Armache, KJ ;

Kettenberger, H ;

Cramer, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) :6964-6968

[2] A ratchet mechanism of transcription elongation and its control [J].

Bar-Nahum, G ;

Epshtein, V ;

Ruckenstein, AE ;

Rafikov, R ;

Mustaev, A ;

Nudler, E .

CELL, 2005, 120 (02) :183-193

[3] Temperature, template topology, and factor requirements of archaeal transcription [J].

Bell, SD ;

Jaxel, C ;

Nadal, M ;

Kosa, PF ;

Jackson, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15218-15222

[4] Mechanism and regulation of transcription in archaea [J].

Bell, SD ;

Jackson, SP .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (02) :208-213

[5] Organization of an Activator-Bound RNA Polymerase Holoenzyme [J].

Bose, Daniel ;

Pape, Tillmann ;

Burrows, Patricia C. ;

Rappas, Mathieu ;

Wigneshweraraj, Siva R. ;

Buck, Martin ;

Zhang, Xiaodong .

MOLECULAR CELL, 2008, 32 (03) :337-346

[6] Structural basis of transcription: An RNA polymerase II-TFIIB cocrystal at 4.5 angstroms [J].

Bushnell, DA ;

Westover, KD ;

Davis, RE ;

Kornberg, RD .

SCIENCE, 2004, 303 (5660) :983-988

[7] Complete, 12-subunit RNA polymerase II at 4.1-Å resolution:: Implications for the initiation of transcription [J].

Bushnell, DA ;

Kornberg, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) :6969-6973

[8] Structural basis of transcription:: α-Amanitin-RNA polymerase II cocrystal at 2.8 A resolution [J].

Bushnell, DA ;

Cramer, P ;

Kornberg, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1218-1222

[9] Nucleic acid polymerases use a general acid for nucleotidyl transfer [J].

Castro, Christian ;

Smidansky, Eric D. ;

Arnold, Jamie J. ;

Maksimchuk, Kenneth R. ;

Moustafa, Ibrahim ;

Uchida, Akira ;

Gotte, Matthias ;

Konigsberg, William ;

Cameron, Craig E. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (02) :212-218

[10] The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex [J].

Chen, Hung-Ta ;

Warfield, Linda ;

Hahn, Steven .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (08) :696-703

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