RNA polymerase II transcription: Structure and mechanism

被引:105
作者
Liu, Xin [1 ]
Bushnell, David A. [1 ]
Kornberg, Roger D. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2013年 / 1829卷 / 01期
关键词
TFIIB; Trigger loop; Bridge helix; Backtracked state; Hybrid helix melting; CORE PROMOTER ELEMENT; TATA-BINDING PROTEIN; C-TERMINAL DOMAIN; DNA-BINDING; CRYSTAL-STRUCTURE; POLYCISTRONIC TRANSCRIPTION; ARCHAEAL TRANSCRIPTION; FACTOR REQUIREMENTS; ELONGATION COMPLEX; ACTIVE-CENTER;
D O I
10.1016/j.bbagrm.2012.09.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five general transcription factors (GTFs) TFIIB, -D, -E, -F, and -H. The addition of Mediator enables a response to regulatory factors. The GTFs are required for promoter recognition and the initiation of transcription. Following initiation, pol II alone is capable of RNA transcript elongation and of proofreading. Structural studies reviewed here reveal roles of GTFs in the initiation process and shed light on the transcription elongation mechanism. This article is part of a Special Issue entitled: RNA Polymerase II Transcript Elongation. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:2 / 8
页数:7
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