Simple, rapid, and sensitive electrochemical determination of antithyroid drug methimazole using a boron-doped diamond electrode

被引：19
|
作者：
Seyidahmet, Safanur [1 ]
Donmez, Fatih [1 ]
Yardim, Yavuz [1 ]
Senturk, Zuehre [2 ]
机构：
[1] Van Yuzuncu Yil Univ, Dept Analyt Chem, Fac Pharm, TR-65080 Van, Turkey
[2] Van Yuzuncu Yil Univ, Dept Analyt Chem, Fac Sci, TR-65080 Van, Turkey
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2019年 / 16卷 / 05期
关键词：
Methimazole; Anodically pretreated boron-doped diamond electrode; Square wave voltammetry; Pharmaceutical samples; ADSORPTIVE STRIPPING VOLTAMMETRY; ENHANCED RAMAN-SCATTERING; SPECTROPHOTOMETRIC DETERMINATION; ANIONIC SURFACTANT; GAS-CHROMATOGRAPHY; CARBON; URINE; PERFORMANCE; SAMPLES; NANOCOMPOSITE;
D O I：
10.1007/s13738-018-1562-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper aims a rapid, cheap, simple and modification-free electroanalytical methodology using a boron-doped diamond electrode pretreated anodically for the determination of antithyroid drug methimazole in pharmaceutical samples. The drug was irreversibly oxidized which was a diffusion-controlled process. Using square wave voltammetry, a linear response was obtained for methimazole determination in Britton-Robinson buffer (pH 5.0) at +0.89V (vs. Ag/AgCl). Linearity was found between the oxidation peak currents and the concentration of methimazole from 0.5 to 25.0 mu g mL(-1) (4.38x10(-6)-2.19x10(-4)M) with a detection limit of 0.085 mu g mL(-1) (7.45x10(-7) M). The proposed method was applied for the determination of methimazole in commercial tablet samples.
引用
收藏
页码：913 / 920
页数：8
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