Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease

被引：53

作者：

Ingelfinger, Julie R. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, MassGen Hosp Children, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2009年 / 18卷 / 01期

关键词：

angiotensin-converting enzyme; angiotensin-converting enzyme 2; angiotensin; 1-7; 1-9; angiotensin II; renin-angiotensin system; GENE ACE2 POLYMORPHISMS; ANGIOTENSIN-CONVERTING-ENZYME-2; EXPRESSION; ASSOCIATION; HEART; OVEREXPRESSION; HYPERTENSION; INHIBITION; INJURY;

D O I：

10.1097/MNH.0b013e32831b70ad

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Angiotensin-converting enzyme 2 (ACE 2), the main product of which is Ang 1-7, which binds to its receptor, Mas, is an important member of the renin-angiotensin system. Recent findings A substantial body of research indicates that ACE2 is cardioprotective and renoprotective. ACE2 participates in a pathway that is counterregulatory to the effects of angiotensin II (Ang II). The mechanisms by which the protective effects of ACE2 occur are just beginning to be elucidated. Summary As ACE2 appears to exert protective effects within the kidney and vasculature, recent data indicate that how it is expressed, what regulates it, and how it interacts with other biological systems may ultimately have clinical implications.

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页码：79 / 84

页数：6

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