Bromine-containing alkaloids from the marine sponge Penares sp.

被引：31

作者：

Lyakhova, Ekaterina G. ^{[1
]}

Kolesnikova, Sophia A. ^{[1
]}

Kalinovsky, Anatoly I. ^{[1
]}

Afiyatullov, Shamil Sh. ^{[1
]}

Dyshlovoy, Sergey A. ^{[1
]}

Krasokhin, Vladimir B. ^{[1
]}

Minh, Chau V. ^{[2
]}

Stonik, Valentin A. ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 45期

关键词：

Marine alkaloids; Sponge; Penares sp; Carbazole; Indolophenanthridine; Tumor cells; METABOLITES; ANALOGS;

D O I：

10.1016/j.tetlet.2012.08.148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new unusual alkaloids were isolated from the sponge Penares sp., collected from Viet Nam waters (the South China Sea). The structures of these compounds were established by analysis of 10, 20 NMR (H-1-H-1 COSY, DEPT, HSQC, HMBC, H2BC, and NOE), and MS data. Compound 1 shows moderate cytotoxicity against the human tumor cells HL-60 and HeLa. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6119 / 6122

页数：4

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