Resistance to Two Heterologous Neurotropic Oncolytic Viruses, Semliki Forest Virus and Vaccinia Virus, in Experimental Glioma

被引：19

作者：

Vaha-Koskela, Markus J. V. ^{[1
,2
]}

Le Boeuf, Fabrice ^{[1
]}

Lemay, Chantal ^{[1
]}

De Silva, Naomi ^{[1
]}

Diallo, Jean-Simon ^{[1
]}

Cox, Julie ^{[1
]}

Becker, Michelle ^{[1
]}

Choi, Youngmin ^{[1
]}

Ananth, Abhirami ^{[1
]}

Sellers, Clara ^{[1
]}

Breton, Sophie ^{[1
]}

Roy, Dominic ^{[1
]}

Falls, Theresa ^{[1
]}

Brun, Jan ^{[3
]}

Hemminki, Akseli ^{[2
]}

Hinkkanen, Ari ^{[4
]}

Bell, John C. ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Ctr Innovat Canc Therapeut, Ottawa, ON, Canada

[2] Univ Helsinki, Mol Canc Biol Program, FIN-00014 Helsinki, Finland

[3] Childrens Hosp Eastern Ontario, Apoptosis Res Inst, Ottawa, ON K1H 8L1, Canada

[4] Univ Eastern Finland, Canc Ctr Eastern Finland, AI Virtanen Inst Mol Med, Kuopio, Finland

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 04期

基金：

芬兰科学院; 加拿大健康研究院;

关键词：

INTERFERON RESPONSE; IN-VITRO; VIROTHERAPY; COMBINATION; INFECTION; IMMUNITY; THERAPY; TARGETS; CELLS;

D O I：

10.1128/JVI.01609-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Attenuated Semliki Forest virus (SFV) may be suitable for targeting malignant glioma due to its natural neurotropism, but its replication in brain tumor cells may be restricted by innate antiviral defenses. We attempted to facilitate SFV replication in glioma cells by combining it with vaccinia virus, which is capable of antagonizing such defenses. Surprisingly, we found parenchymal mouse brain tumors to be refractory to both viruses. Also, vaccinia virus appears to be sensitive to SFV-induced antiviral interference.

引用

页码：2363 / 2366

页数：4

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