Cooling inhibits capsaicin-induced currents in cultured rat dorsal root ganglion neurones

被引：36
|
作者：
Babes, A
Amuzescu, B
Krause, U
Scholz, A
Flonta, ML
Reid, G
机构：
[1] Univ Bucharest, Dept Anim Physiol & Biophys, Fac Biol, Bucharest 76201, Romania
[2] Univ Giessen, Inst Physiol, D-35392 Giessen, Germany
来源：
NEUROSCIENCE LETTERS | 2002年 / 317卷 / 03期
关键词：
vanilloid receptor 1 (VR1); cold; inflammation; nociceptor; pain; primary sensory neurone;
D O I：
10.1016/S0304-3940(01)02443-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Whole-cell and single-channel recordings from rat dorsal root ganglion neurones were used to investigate the temperature dependence of currents through the capsaicin receptor (vanilloid receptor 1, VR1). Reducing the temperature from 31 to 14degreesC inhibited the current induced by 0.5 muM capsaicin by 80%. The Q(10) (temperature coefficient over a 10degreesC range) of the whole-cell capsaicin-induced current was 2.3 between 10 and 30degreesC. Single-channel recordings showed that this inhibition by cooling was due to a marked reduction in the open probability (Q(10) = 8.2 between 10 and 30degreesC). his effect can explain the pain relief and reduction in inflammation caused by strong cooling of the skin. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 134
页数：4
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