Tumor cell recognition by the NK cell activating receptor NKG2D

被引：35

作者：

Bryceson, Yenan T. ^{[1
]}

Ljunggren, Hans-Gustaf ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Infect Med, Dept Med, S-14186 Huddinge, Sweden

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 11期

关键词：

Co-activation; Immune escape; Immunotherapy; NK cells; NKG2D;

D O I：

10.1002/eji.200838833

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evidence for increased tumor incidence in NKG2D-deficient mice has set NKG2D as the first innate immune receptor implicated in immuno-surveillance of tumors. In this viewpoint article, we discuss recent genetic insight into NKG2D-mediated suppression of spontaneous tumor development in the context of NKG2D signaling properties. Moreover, we identify unresolved issues and consider how an understanding of NKG2D-receptor and -ligand biology can facilitate successful therapeutic intervention of human cancer.

引用

页码：2957 / 2961

页数：5

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