Room-Temperature Photoinduced Direct C-H-Arylation via Base-Promoted Homolytic Aromatic Substitution

被引：138

作者：

Buden, Maria E. ^{[1
]}

Guastavino, Javier F. ^{[1
]}

Rossi, Roberto A. ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Quim Organ, INFIQC, RA-5000 Cordoba, Argentina

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 06期

关键词：

ELECTRON-TRANSFER REACTIONS; POTASSIUM TERT-BUTOXIDE; ARYL HALIDES; UNACTIVATED ARENES; COUPLING REACTIONS; BOND FORMATION; ACTIVATION; BENZENE; DERIVATIVES; PRODUCTS;

D O I：

10.1021/ol3034687

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conceptually different approach toward biaryl syntheses by photoinduced direct C-H arylation of benzene and thiophene in the presence of t-BuOK is reported. The reaction proceeds through photo- and base-promoted homolytic aromatic substitution. The o-, m- and p- substituted Ad, as well as the electron-donating and electron-withdrawing nature of the substituents were found be good to excellent substrates. Heteroaryl, ArBr, ArCl and double C-H arylation were successfully achieved.

引用

页码：1174 / 1177

页数：4

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