Room-Temperature Photoinduced Direct C-H-Arylation via Base-Promoted Homolytic Aromatic Substitution

被引：138
|
作者：
Buden, Maria E. [1 ]
Guastavino, Javier F. [1 ]
Rossi, Roberto A. [1 ]
机构：
[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Quim Organ, INFIQC, RA-5000 Cordoba, Argentina
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 06期
关键词：
ELECTRON-TRANSFER REACTIONS; POTASSIUM TERT-BUTOXIDE; ARYL HALIDES; UNACTIVATED ARENES; COUPLING REACTIONS; BOND FORMATION; ACTIVATION; BENZENE; DERIVATIVES; PRODUCTS;
D O I：
10.1021/ol3034687
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Conceptually different approach toward biaryl syntheses by photoinduced direct C-H arylation of benzene and thiophene in the presence of t-BuOK is reported. The reaction proceeds through photo- and base-promoted homolytic aromatic substitution. The o-, m- and p- substituted Ad, as well as the electron-donating and electron-withdrawing nature of the substituents were found be good to excellent substrates. Heteroaryl, ArBr, ArCl and double C-H arylation were successfully achieved.
引用
收藏
页码：1174 / 1177
页数：4
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