Structure and function of bak gene and its apoptosis-inducing mechanism

被引：2
|
作者：
Li, Y [1 ]
Qi, YP [1 ]
Xiao, GF [1 ]
机构：
[1] Wuhan Univ, Inst Virol, Wuhan 430072, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 1999年 / 44卷 / 07期
关键词：
programmed cell death; apoptosis; Bcl-2; family; bak;
D O I：
10.1007/BF03182718
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Bcl-2 family plays an important role in the regulation of apoptosis. Some members in the family prevent apoptosis while others promote it. The newly discovered bcl-2 homolog, bak, promotes the apoptosis induced by a variety of stimuli. It can interact with the anti-apoptotic members through its BH3 domain and antagonize their activity. Investigation results suggest that the expression of bak gene becomes altered in some diseases, such as cancer. The preferential stimulation of Bak-induced apoptosis, therefore, may be involved in the mechanisms of some antitumor drugs.
引用
收藏
页码：605 / 609
页数：5
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