Exploring the Validity of Valproic Acid Animal Model of Autism

被引：185

作者：

Mabunga, Darine Froy N. ^{[1
,2
,3
]}

Gonzales, Edson Luck T. ^{[1
,2
,3
]}

Kim, Ji-woon ^{[1
,2
,3
]}

Kim, Ki Chan ^{[1
,2
,3
]}

Shin, Chan Young ^{[1
,2
,3
,4
]}

机构：

[1] Konkuk Univ, Dept Neurosci, Sch Med, Seoul 05029, South Korea

[2] Konkuk Univ, Neurosci Res Ctr, SMART IABS, Seoul 05029, South Korea

[3] Konkuk Univ, KU Open Innovat Ctr, Seoul 05029, South Korea

[4] Konkuk Univ, Sch Med, Dept Pharmacol, Seoul 05029, South Korea

来源：

EXPERIMENTAL NEUROBIOLOGY | 2015年 / 24卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

autism spectrum disorder; construct validity; face validity; predictive validity; animal model; social communication deficit; INCREASED OXIDATIVE STRESS; NEURAL-TUBE DEFECTS; SPECTRUM DISORDERS; PRENATAL EXPOSURE; ENVIRONMENTAL ENRICHMENT; REPETITIVE BEHAVIOR; SOCIAL-INTERACTION; THERAPEUTIC APPROACH; ADDITIONAL EVIDENCE; MENTAL-RETARDATION;

D O I：

10.5607/en.2015.24.4.285

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the structural and behavioral features that can be observed in individuals with autism. These similarities enable the model to define relevant pathways of developmental dysregulation resulting from environmental manipulation. The uncovering of these complex pathways resulted to the growing pool of potential therapeutic candidates addressing the core symptoms of ASD. Here, we summarize the validity points of VPA that may or may not qualify it as a valid animal model of ASD.

引用

页码：285 / 300

页数：16

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