Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

被引：30

作者：

Boschiero, Clarissa ^{[1
]}

Jorge, Erika C. ^{[2
]}

Ninov, Kerli ^{[2
]}

Nones, Katia ^{[2
]}

do Rosario, Millor Fernandes ^{[2
]}

Coutinho, Luiz Lehmann ^{[2
]}

Ledur, Monica Correa ^{[3
]}

Burt, David W. ^{[4
,5
]}

Moura, Ana Silvia A. M. T. ^{[1
]}

机构：

[1] Univ Estadual Paulista UNESP, Dept Prod Anim, FMVZ, BR-18618970 Botucatu, SP, Brazil

[2] Univ Sao Paulo, ESALQ, Dept Zootecnia, BR-13418900 Piracicaba, SP, Brazil

[3] Embrapa Suinos & Aves, BR-89700000 Concordia, SC, Brazil

[4] Univ Edinburgh, Div Genet & Genom, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland

[5] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH25 9RG, Midlothian, Scotland

来源：

JOURNAL OF APPLIED GENETICS | 2013年 / 54卷 / 01期

基金：

巴西圣保罗研究基金会; 英国生物技术与生命科学研究理事会;

关键词：

Abdominal fat; Additive effect; Body weight; Feed intake; Haematocrit; SNP; MUSCLE DEVELOPMENT; BODY-COMPOSITION; GROWTH-FACTORS; INSULIN; INSULIN-LIKE-GROWTH-FACTOR-1; GENE; RECEPTOR; BONE; DIFFERENTIATION; PROLIFERATION;

D O I：

10.1007/s13353-012-0129-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F-2 chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype x sex interactions. KDM5A SNP c.34208C > T genotype x sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype x sex interaction (p < 0.0001) with abdominal fat was observed, and also associations with body weight, feed intake, percentages of carcass, drums and thighs, gizzard and haematocrit. Our findings suggest that the KDM5A gene might play an important role in the abdominal fat deposition in chickens. The IGF1 and KDM5A genes are strong candidates to explain the QTL mapped in this region of GGA1.

引用

页码：103 / 112

页数：10

共 30 条

[1] Review of quantitative trait loci identified in the chicken [J].

Abasht, B. ;

Dekkers, J. C. M. ;

Lamont, S. J. .

POULTRY SCIENCE, 2006, 85 (12) :2079-2096

[2] Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits [J].

Amills, M ;

Jiménez, N ;

Villalba, D ;

Tor, M ;

Molina, E ;

Cubiló, D ;

Marcos, C ;

Francesch, A ;

Sànchez, A ;

Estany, J .

POULTRY SCIENCE, 2003, 82 (10) :1485-1493

[3] Even small SNP clusters are non-randomly distributed: is this evidence of mutational non-independence? [J].

Amos, William .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 277 (1686) :1443-1449

[4] Binding of pRB to the PHD protein RBP2 promotes cellular differentiation [J].

Benevolenskaya, EV ;

Murray, HL ;

Branton, P ;

Young, RA ;

Kaelin, WG .

MOLECULAR CELL, 2005, 18 (06) :623-635

[5] Polymorphisms in vitamin D receptor, osteopontin, insulin-like growth factor 1 and insulin, and their associations with bone, egg and growth traits in a layer -: broiler cross in chickens [J].

Bennett, A. K. ;

Hester, P. Y. ;

Spurlock, D. E. M. .

ANIMAL GENETICS, 2006, 37 (03) :283-286

[6] Variation at the insulin-like growth factor 1 gene and its association with body weight traits in the chicken [J].

Bian, L. H. ;

Wang, S. Z. ;

Wang, Q. G. ;

Zhang, S. ;

Wang, Y. X. ;

Li, H. .

JOURNAL OF ANIMAL BREEDING AND GENETICS, 2008, 125 (04) :265-270

[7] Ontogenic variations in the content and distribution of progesterone receptor isoforms in the reproductive tract and brain of chicks [J].

Camacho-Arroyo, Ignacio ;

Gonzalez-Arenas, Aliesha ;

Gonzalez-Moran, Genoveva .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2007, 146 (04) :644-652

[8] RBP2 belongs to a family of demethylases, specific for tri- and dimethylated lysine 4 on histone 3 [J].

Christensen, Jesper ;

Agger, Karl ;

Cloos, Paul A. C. ;

Pasini, Diego ;

Rose, Simon ;

Sennels, Lau ;

Rappsilber, Juri ;

Hansen, Klaus H. ;

Salcini, Anna Elisabetta ;

Helin, Kristian .

CELL, 2007, 128 (06) :1063-1076

[9] Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome [J].

Clark, AG ;

Nielsen, R ;

Signorovitch, J ;

Matise, TC ;

Glanowski, S ;

Heil, J ;

Winn-Deen, ES ;

Holden, AL ;

Lai, E .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (02) :285-300

[10] Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock [J].

DiTacchio, Luciano ;

Le, Hiep D. ;

Vollmers, Christopher ;

Hatori, Megumi ;

Witcher, Michael ;

Secombe, Julie ;

Panda, Satchidananda .

SCIENCE, 2011, 333 (6051) :1881-1885

← 1 2 3 →