TGF-β:: A master of all T cell trades

被引：729

作者：

Li, Ming O. ^{[1
]}

Flavell, Richard A. ^{[2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

CELL | 2008年 / 134卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained in the peripheral lymphoid organs. Recent studies have defined the cytokine transforming growth factor-β (TGF-β) as a critical regulator of thymic T cell development as well as a crucial player in peripheral T cell homeostasis, tolerance to self antigens, and T cell differentiation during the immune response. The unique mechanism of TGF-β activation and the plasticity of TGF-β signaling create a stage for TGF-β to integrate signals from multiple cell types and environmental cues to regulate T cells. © 2008 Elsevier Inc. All rights reserved.

引用

页码：392 / 404

页数：13

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