Dyserythropoiesis evaluated by the RED score and hepcidin: ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes

被引：21

作者：

Park, Sophie ^{[1
,2
]}

Kosmider, Olivier ^{[3
]}

Maloisel, Frederic ^{[4
]}

Drenou, Bernard ^{[5
]}

Chapuis, Nicolas ^{[6
]}

Lefebvre, Thibaud ^{[7
]}

Karim, Zoubida ^{[6
]}

Puy, Herve ^{[6
]}

Alary, Anne Sophie ^{[3
]}

Ducamp, Sarah ^{[7
]}

Verdier, Frederique ^{[7
]}

Bouilloux, Cecile ^{[1
,2
]}

Rousseau, Alice ^{[7
]}

Jacob, Marie-Christine ^{[8
]}

Debliquis, Agathe ^{[9
]}

Charpentier, Agnes ^{[10
]}

Gyan, Emmanuel ^{[11
]}

Anglaret, Bruno ^{[12
]}

Leyronnas, Cecile ^{[13
]}

Corm, Selim ^{[14
]}

Slama, Borhane ^{[15
]}

Cheze, Stephane ^{[16
]}

Laribi, Kamel ^{[17
]}

Ame, Shanti ^{[18
]}

Rose, Christian ^{[19
]}

Lachenal, Florence ^{[20
]}

Toma, Andrea ^{[21
]}

Pica, Gian Matteo ^{[22
]}

Carre, Martin ^{[1
,2
]}

Garban, Frederic ^{[1
,2
]}

Mariette, Clara ^{[1
,2
]}

Cahn, Jean-Yves ^{[1
,2
]}

Meunier, Mathieu ^{[1
,2
]}

Herault, Olivier ^{[23
]}

Fenaux, Pierre ^{[24
]}

Wagner-Ballon, Orianne ^{[25
]}

Bardet, Valerie ^{[26
,27
]}

Dreyfus, Francois ^{[27
]}

Fontenay, Michaela ^{[3
]}

机构：

[1] CHU Grenoble Alpes, Dept Hematol, Grenoble, France

[2] INSERM, U1209, Inst Adv Biosci, CNRS,UMR 5309, Grenoble, France

[3] Univ Paris 05, Hop Univ, AP HP, Serv Hematol Biol,Paris Ctr, Paris, France

[4] Clin St Anne, SOL Hematol, Strasbourg, France

[5] Hop Emile Muller, CH Mulhouse, Dept Hematol, Mulhouse, France

[6] Hop Louis Mourier HUPNVS, Ctr Rech Inflammat CRI Equipe Heme Fer & Pathol I, Ctr Francais Porphyries, INSERM,UMR1149,CNRS 8252,Labex GREX, Paris, France

[7] Paris Descartes Univ, Inst Cochin, INSERM, U1016,CNRS,UMR 8104, Paris, France

[8] CHU Grenoble Alpes, Inst Biol & Pathol, Immunol, Grenoble, France

[9] Mulhouse Hosp, Hematol Lab, Mulhouse, France

[10] Hop St Philibert, Dept Hematol, Lille, France

[11] CHU Tours, Dept Hematol, Tours, France

[12] CH Valence, Valence, France

[13] Inst Daniel Hollard, Grenoble, France

[14] Medipole Savoie, Challes Les Eaux, France

[15] CH Avignon, Dept Hematol, Avignon, France

[16] CHU Caen, Dept Hematol, Caen, France

[17] CH Le Mans, Dept Hematol, Le Mans, France

[18] CHU Strasbourg, Hop Civil, Dept Hematol, Strasbourg, France

[19] Hop St Vincent De Paul, Dept Hematol, Lille, France

[20] CH Pierre Oudot, Dept Hematol, Bourgoin Jallieu, France

[21] Univ Paris 12, Hop Univ Henri Mondor, AP HP, Dept Hematol, Creteil, France

[22] CH Metropole Savoie, Dept Hematol, Chambery, France

[23] CHU Tours, Lab Hematol, Tours, France

[24] Univ Paris Diderot, St Louis Hosp, AP HP, Dept Hematol, Paris, France

[25] Hop Univ Henri Mondor, Dept Hematol & Immunol Biol, Creteil, France

[26] Hop Univ Paris Ile France Ouest, AP HP, Serv Hematol Immunol Transfus, Paris 5, France

[27] Cochin Hosp, Dept Hematol, Paris 5, France

来源：

HAEMATOLOGICA | 2019年 / 104卷 / 03期

关键词：

DIFFERENTIATION FACTOR 15; DARBEPOETIN ALPHA; FLOW-CYTOMETRY; ANEMIA; EXPRESSION; FERROPORTIN; PROGENITORS; DIAGNOSIS; BLASTS; SYSTEM;

D O I：

10.3324/haematol.2018.203158

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There were 22 patients with refractory cytopenia with multilineage dysplasia, 19 with refractory cytopenia with unilineage dysplasia, 14 with refractory anemia with ring sideroblasts, four with refractory anemia with excess blasts-1, six with chronic myelomonocytic leukemia, two with del5qand three with unclassifiable myelodysplastic syndrome. According to the revised International Prognostic Scoring System, 13 had very low risk, 47 had low risk, nine intermediate risk and one had high-risk disease. Twenty patients were transfusion dependent. Forty-eight percent had an erythroid response and the median duration of the response was 26 months. At baseline, non-responders had significantly higher RED scores and lower hepcidin: ferritin ratios. In multivariate analysis, only a RED score > 4 (P=0.05) and a hepcidin: ferritin ratio < 9 (P=0.02) were statistically significantly associated with worse erythroid response. The median response duration was shorter in patients with growth-differentiation factor-15 > 2000 pg/mL and a hepcidin: ferritin ratio < 9 (P=0.0008 and P=0.01, respectively). In multivariate analysis, both variables were associated with shorter response duration. Erythroid response to epoetin zeta was similar to that obtained with other erythropoiesis-stimulating agents and was correlated with higher baseline hepcidin: ferritin ratio and lower RED score. ClinicalTrials. gov registration: NCT 03598582.

引用

页码：497 / 504

页数：8

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